Gallium Trihalide Catalyzed Sequential Addition of Two Different Carbon Nucleophiles to Esters by Using Silyl Cyanide and Ketene Silyl Acetals
Gallium Trihalide Catalyzed Sequential Addition of Two Different Carbon Nucleophiles to Esters by Using Silyl Cyanide and Ketene Silyl Acetals
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三卤化镓催化氰化硅和烯酮甲硅烷基缩醛两种不同碳亲核试剂顺序加成到酯上
DOI：
10.1002/chem.201403734
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Akio Baba
中科院分区：
文献类型：
--
作者：
Yoshihiro Inamoto;Yuta Kaga;Yoshihiro Nishimoto;Makoto Yasuda;Akio Baba
通过三卤化镓催化剂实现了氰硅烷和烯酮甲硅烷基缩醛与酯的顺序加成以产生β-氰基-β-甲硅烷氧基酯。这是将两种不同的碳亲核试剂依次加成到酯上的第一个例子。内酯的使用提供了具有氰基和酯部分的α，α-二取代的环醚。各种酯和内酯都适用于该反应体系。
A sequential addition of silyl cyanide and ketene silyl acetals to esters was achieved by a gallium trihalide catalyst to produce β‐cyano‐β‐siloxy esters. This is the first example of the sequential addition of two different carbon nucleophiles to esters. The employment of lactones provided α,α‐disubstituted cyclic ethers with a cyano group and an ester moiety. A variety of esters and lactones are applicable to this reaction system.