Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population
Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population
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DOI：
10.1016/s0021-9150(99)00477-3
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发表时间：
2000-10-01
期刊：
影响因子：
5.3
通讯作者：
Ordovás, JM
中科院分区：
文献类型：
--
作者：
Corella, D;Sáiz, C;Ordovás, JM
胆固醇酯转移蛋白 (CETP) 位点的遗传变异与 CETP 活性和质量以及血浆高密度脂蛋白胆固醇 (HDL-C) 和载脂蛋白 A-I 水平相关。我们检查了居住在巴伦西亚（西班牙）的 514 名健康受试者（231 名男性，平均年龄 37.4 岁，283 名女性，平均年龄 35.7 岁）样本中常见 CETP TaqIB 多态性的等位基因频率和脂质关联。不太常见的 TaqIB2 等位基因的频率（0.351；95% CI：0.322-0.380）显着低于北欧人群报告的频率。与之前的研究一致，我们发现 TaqIB 多态性与 HDL-C 水平存在显着关联。 B1 等位基因纯合子的 HDL-C 水平低于携带 B2 等位基因的受试者（男性和女性的 P 趋势分别 < 0.001 和 0.002）。对于任何其他脂质测量，没有观察到统计学上显着的基因型效应。拟合包括 TaqIB 基因型、体重指数、吸烟、饮酒、体力活动、婚姻状况和教育程度在内的多变量模型来预测 HDL-C 水平。 TaqIB 多态性始终是 HDL-C 水平的独立预测因子 (P ( 0.001)，并解释了其方差的 5.8%。为了评估基因-环境相互作用，在多变量模型中测试了一级相互作用项。未检测到 TaqIB 基因型与吸烟、饮酒、体力活动或教育之间存在统计学上显着的相互作用。总而言之，我们观察到 TaqIB 多态性与 HDL-C 水平存在显着关联，并且在不同水平的 HDL-C 中保持一致。此外，我们发现我们样本中的 TaqIB2 等位基因频率低于其他欧洲人群，这可能是巴伦西亚地区冠心病患病率意外高的一个因素。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Genetic variants at the cholesteryl ester transfer protein (CETP) locus have been associated with CETP activity and mass, as well as plasma high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I levels. We have examined allele frequencies and lipid associations for the common CETP TaqIB polymorphism in a sample of 514 healthy subjects (231 men, mean age 37.4 years, and 283 women, mean age 35.7 years) residing in Valencia (Spain). The frequency of the less common TaqIB2 allele (0.351; 95% CI: 0.322-0.380) was significantly lower than those reported for Northern European populations. Consistent with previous studies, we found a significant association of the TaqIB polymorphism with HDL-C levels. Homozygotes for the B1 allele had lower HDL-C levels than subjects carrying the B2 allele (P trend < 0.001 and 0.002, for men and women, respectively). No statistically significant genotype effects were observed for any of the other lipid measures. Multivariate models including TaqIB genotype, body mass index, smoking, alcohol, physical activity, marital status and education were fitted to predict HDL-C levels. The TaqIB polymorphism was consistently an independent predictor of HDL-C levels (P ( 0.001), and explained 5.8% of its variance. To evaluate gene-environmental interactions, first order interaction terms were tested into the multivariate model. No statistically significant interactions between the TaqIB genotypes and smoking, alcohol, physical activity or education were detected. In conclusion, we observed a significant association of the TaqIB polymorphism with HDL-C levels, which remained consistent across different levels of behavioral factors. Moreover, we found that the TaqIB2 allele frequency was lower in our sample than in other European populations, which could be a contributing factor to the unexpectedly high prevalence of coronary heart disease observed in the region of Valencia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.