Suppression of gamma interferon production by inactivated feline leukemia virus.
Suppression of gamma interferon production by inactivated feline leukemia virus.
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灭活猫白血病病毒抑制γ干扰素的产生。
DOI：
10.1126/science.2983424
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Day,NK
中科院分区：
文献类型：
--
作者：
Engelman,RW;Fulton,RW;Good,RA;Day,NK
用葡萄球菌肠毒素A刺激的正常猫淋巴细胞培养上清液显示抗病毒活性，其特征为γ-样干扰素。加入灭活的猫白血病病毒后，产生的干扰素明显减少。干扰素产生的减少不是由于淋巴细胞活力降低或葡萄球菌肠毒素A的促有丝分裂特性降低，似乎是一种直接的逆转录病毒效应。这一发现可能反映了可能导致猫或人类获得性免疫缺陷状态发展的临床相关事件。
Supernatants from cultures of normal feline lymphocytes stimulated withStaphylococcusenterotoxin A showed antiviral activity, characterized as a gamma-like interferon. With the addition of inactivated feline leukemia virus, markedly less interferon was produced. The reduction in interferon production was not attributable to lowered lymphocyte viability or reduced mitogenic properties ofStaphylococcusenterotoxin A and appears to be a direct retroviral effect. This finding may reflect clinically relevant events that may contribute to the development of the feline or human states of acquired immunodeficiency.