Differing amygdala responses to facial expressions in children and adults with bipolar disorder.
Differing amygdala responses to facial expressions in children and adults with bipolar disorder.
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DOI：
10.1176/appi.ajp.2012.11081245
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Leibenluft E
中科院分区：
文献类型：
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作者：
Kim P;Thomas LA;Rosen BH;Moscicki AM;Brotman MA;Zarate CA Jr;Blair RJ;Pine DS;Leibenluft E
双相情感障碍（BD）在儿童和成人中都是高度衰弱的。儿童和成人BD患者都表现出面部情绪加工的行为缺陷和异常杏仁核激活。然而，儿童与成人BD患者的杏仁核功能从未被直接比较。本研究比较了74名受试者[BD儿童（N=18）和成人（N=17）患者，健康志愿者（HV）儿童（N=15）和成人（N=22）]对情感面部表情的杏仁核反应。受试者在观看恐惧、愤怒和中性面孔时进行性别识别任务。面对恐惧的面孔，各年龄组的BD患者相对于健康志愿者表现出右杏仁核过度活跃。然而，当所有面部表情的反应相结合，儿童患者表现出更大的右杏仁核激活比成人BD或HV儿童。杏仁核对恐惧面孔的反应亢进存在于青少年和成人BD患者中。然而，与成年BD患者或健康青年相比，BD青年在对各种情绪面孔做出反应时表现出杏仁核过度活跃。因此，在面部处理过程中异常杏仁核激活似乎比成人BD儿童更普遍。
Bipolar disorder (BD) is highly debilitating in both children and adults. Child and adult BD patients show both behavioral deficits in face emotion processing and abnormal amygdala activation. However, amygdala function in pediatric vs. adult BD patients has never been compared directly. This study compared amygdala responses to emotional facial expressions in 74 subjects [pediatric (N=18) and adult (N=17) patients with BD, healthy volunteer (HV) children (N=15) and adults (N=22)]. Subjects performed a gender identification task while viewing fearful, angry, and neutral faces. In response to fearful faces, patients with BD across age-groups showed right amygdala hyperactivity relative to healthy volunteers. However, when responses to all facial expressions were combined, pediatric patients exhibited greater right amygdala activation than either adults with BD or HV children. Amygdala hyperactivity in response to fearful faces is present in both youths and adults with BD. However, compared to adults with BD or healthy youths, youths with BD show amygdala hyperactivity in response to a broad array of emotional faces. Thus, abnormal amygdala activation during face processing appears to be more pervasive in children than adults with BD.