An atlas of the protein-coding genes in the human, pig, and mouse brain
An atlas of the protein-coding genes in the human, pig, and mouse brain
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DOI：
10.1126/science.aay5947
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发表时间：
2020-03-06
期刊：
影响因子：
56.9
通讯作者：
Mulder, Jan
中科院分区：
文献类型：
--
作者：
Sjostedt, Evelina;Zhong, Wen;Mulder, Jan
大脑是哺乳动物身体中最复杂的器官，具有多样的生理机能和复杂的细胞组织。为了扩大我们对大脑及其疾病的神经生物学的基本了解，我们使用各种转录组学方法和基于抗体的制图对10个主要大脑区域和多个亚区进行了全面的分子解剖。该分析在人类、猪和小鼠大脑中进行，以确定区域表达谱，并研究三种物种之间表达水平的异同。结果数据已经在一个开放获取的Brain Atlas资源中提供，该资源是人类蛋白质图谱的一部分，允许探索和比较哺乳动物大脑不同部位的单个蛋白质编码基因的表达。
The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.