VITAMIN-A SUPPLEMENTS AND MORTALITY RELATED TO MEASLES - A RANDOMIZED CLINICAL-TRIAL
VITAMIN-A SUPPLEMENTS AND MORTALITY RELATED TO MEASLES - A RANDOMIZED CLINICAL-TRIAL
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DOI：
10.1136/bmj.294.6567.294
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发表时间：
1987-01-31
影响因子：
105.7
通讯作者：
SOMMER, A
中科院分区：
文献类型：
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作者：
BARCLAY, AJG;FOSTER, A;SOMMER, A
180 名因麻疹入院的儿童被随机分配接受单独常规治疗或额外接受大剂量维生素 A（立即口服 200 000 IU，第二天再次口服）。两组的基线特征在年龄、麻疹严重程度、维生素 A 和一般营养状况方面几乎相同。 91% 的儿童血清维生素 A 浓度低于 0.56 μmol/l。在 88 名服用维生素 A 补充剂的受试者中，有 6 名 (7%) 死亡；在 92 名对照组中，有 12 名 (13%) 死亡 (p = 0.13)。这种死亡率差异在 2 岁以下儿童中最为明显（接受补充剂的 46 名儿童中有 1 人死亡，而 42 名对照儿童中有 7 人死亡；p < 0.05）以及并发哮吼或喉气管支气管炎的病例。无论研究分配如何，消瘦儿童的死亡率比营养较好的儿童高几倍（p < 0.01）。
One hundred and eighty children admitted with measles were randomly allocated to receive routine treatment alone or with additional large doses of vitamin A (200 000 IU orally immediately and again the next day). Baseline characteristics of the two groups were virtually identical for age, severity of measles, and vitamin A and general nutritional states. In 91% of the children serum vitamin A concentrations were less than 0.56 .mu.mol/l. Of the 88 subjects given vitamin A supplements, six (7%) died; of the 92 controls, 12 (13%) died (p = 0.13). This difference in mortality was most obvious for children aged under 2 years (one death out of 46 children receiving supplements versus seven deaths out of 42 controls; p < 0.05) and for cases complicated by croup or laryngotracheobronchitis. Mortality was several times higher in marasmic than in better nourished children, regardless of study allocation (p < 0.01).