Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes
Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes
复制标题
DOI：
10.7326/0003-4819-132-8-200004180-00002
复制
发表时间：
2000-04-18
影响因子：
39.2
通讯作者：
Blair, SN
中科院分区：
文献类型：
--
作者：
Wei, M;Gibbons, LW;Blair, SN
背景资料：虽然体力活动被推荐作为糖尿病患者的基本治疗，但其与这些患者死亡率的长期关系尚不清楚。目的：评估低心肺功能和缺乏体力活动与男性2型糖尿病患者死亡率的关系。设计：前瞻性队列研究。设置：预防医学诊所。患者：1 263名男性1970年至1993年期间接受全面医学检查的2型糖尿病患者（50 +/- 10岁），随访死亡率至1994年12月31日。通过最大运动试验测量的呼吸适应性，基线时自我报告的身体活动不足，结果：在平均12年的随访中，180例患者死亡。校正年龄、基线心血管疾病、空腹血糖水平、高胆固醇水平、超重、目前吸烟、高血压和父母心血管疾病史后，与健康男性相比，低健康组男性的全因死亡率校正风险为2.1（95%CI，1.5 - 2.9）。男性谁报告被体力活动有调整后的死亡率的风险是1.7倍（CI，1.2倍至2.3倍）高于男性谁报告被体力activity.Conclusions：低心肺功能和体力活动是独立的预测因子的男性2型糖尿病全因死亡率。医生应该鼓励2型糖尿病患者参加定期的体育活动，改善心肺功能。
Background: Although physical activity is recommended as a basic treatment for patients with diabetes, its longterm association with mortality in these patients is unknown.Objective: To evaluate the association of low cardiorespiratory fitness and physical inactivity with mortality in men with type 2 diabetes.Design: Prospective cohort study.Setting: Preventive medicine clinic.Patients: 1263 men (50 +/- 10 years of age) with type 2 diabetes who received a thorough medical examination between 1970 and 1993 and were followed for mortality up to 31 December 1994.Measurements: Cardiorespiratory fitness measured by a maximal exercise test, self-reported physical inactivity at baseline, and subsequent death determined by using the National Death Index.Results: During an average follow-up of 12 years, 180 patients died. After adjustment for age, baseline cardiovascular disease, fasting plasma glucose level, high cholesterol level, overweight, current smoking, high blood pressure, and parental history of cardiovascular disease, men in the low-fitness group had an adjusted risk for all-cause mortality of 2.1 (95% Cl, 1.5 to 2.9) compared with fit men. Men who reported being physically inactive had an adjusted risk for mortality that was 1.7-fold (Cl, 1.2-fold to 2.3-fold) higher than that in men who reported being physically active.Conclusions: Low cardiorespiratory fitness and physical inactivity are independent predictors of all-cause mortality in men with type 2 diabetes. Physicians should encourage patients with type 2 diabetes to participate in regular physical activity and improve cardiorespiratory fitness.