Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents.
Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents.
复制标题
多乳酸 - 糖苷糖纳米颗粒，用于控制抗癌剂的递送。
DOI：
10.2147/ijn.s18905
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发表时间：
2011
影响因子：
8
通讯作者：
Atyabi F
中科院分区：
文献类型：
--
作者：
Dinarvand R;Sepehri N;Manoochehri S;Rouhani H;Atyabi F
抗癌剂的有效性可能受到水溶性低、渗透性差和细胞外排高的阻碍。纳米材料已被用于实现对健康细胞具有较低毒性的药物递送和增强对肿瘤细胞的药物递送。已经使用具有或不具有表面改性的不同聚合物开发了不同的纳米颗粒，以被动和/或主动地靶向肿瘤细胞。聚丙交酯-共-乙交酯（PLGA）是一种批准用于人体的可生物降解聚酯，已被广泛使用。在这里，我们报告了最近的发展有关PLGA纳米粒子制备用于癌症治疗。我们回顾了用于制备和表征PLGA纳米颗粒及其在递送一些活性剂中的应用的方法。PLGA纳米颗粒的制备、表征和体内应用领域的经验不断增加，为这些药物在癌症治疗中有前途的未来应用提供了必要的动力，具有更高的疗效和更少的副作用。
The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.