NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps
NOrmalized MAgnetization Ratio (NOMAR) filtering for creation of tissue selective contrast maps
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DOI：
10.1002/mrm.24271
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发表时间：
2013-02-01
影响因子：
3.3
通讯作者：
McMahon, Michael T.
中科院分区：
文献类型：
--
作者：
Liu, Guanshu;Chan, Kannie W. Y.;McMahon, Michael T.
提出了一种基于收集两个额外的饱和转移图像的MRI分割技术，作为改进的化学交换饱和转移剂检测的辅助手段。在该方法中，在-12.5和-50 ppm的饱和频率下采集附加图像。使用这些图像的比率允许使用由直方图分析确定的全局阈值将具有低磁化传递对比度的体素（诸如脂肪、脑脊液、水肿或血液）与目标组织体素区分开。我们证明，这种技术可以减少文物，在体外，在一个幻影含有管与化学交换饱和转移造影剂嵌入在交联牛血清白蛋白或缓冲液，并在体内检测抗磁性CEST（DIACEST）脂质体注射到小鼠。Magn Reson Med，2013年。(C)2012 Wiley Periodicals，Inc.
An MRI segmentation technique based on collecting two additional saturation transfer images is proposed as an aid for improved detection of chemical exchange saturation transfer agents. In this approach, the additional images are acquired at saturation frequencies of -12.5 and -50 ppm. Use of the ratio of these images allows differentiation of voxels with low magnetization transfer contrast (such as fat, cerebrospinal fluid, edema, or blood) from target tissue voxels using a global threshold determined by histogram analysis. We demonstrate that this technique can reduce artifacts, in vitro, in a phantom containing tubes with chemical exchange saturation transfer contrast agent embedded in either crosslinked bovine serum albumin or buffer, and in vivo for detecting diamagnetic CEST (DIACEST) liposomes injected into mice. Magn Reson Med, 2013. (C) 2012 Wiley Periodicals, Inc.