Mortality from solid cancers among workers in formaldehyde industries
Mortality from solid cancers among workers in formaldehyde industries
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DOI：
10.1093/aje/kwh174
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发表时间：
2004-06-15
影响因子：
5
通讯作者：
Blair, A
中科院分区：
文献类型：
--
作者：
Hauptmann, M;Lubin, JH;Blair, A
在工业工人中，甲醛暴露与鼻腔癌、鼻咽癌、前列腺癌、肺癌和胰腺癌有关;然而，这些关联是不一致的，仍然存在争议。暴露在甲醛中的动物会患上过多的鼻癌。在一项对大量暴露于甲酰胺的工人进行的长期随访中，作者评估了1994年美国10个生产或使用甲酰胺的设施中雇用的25，619名工人（865，708人-年）的实体癌死亡率（1，921人死亡）。暴露评估包括对甲醛暴露的定量估计。计算标准化死亡率和相对危险度。与美国人群相比，暴露于和未暴露于甲醛的受试者中实体癌的死亡率显著低于预期（标准化死亡率分别为0.91和0.78）。鼻咽癌的相对风险（9例死亡）随着甲醛的平均暴露强度、累积暴露、最高峰值暴露和暴露时间的增加而增加（p趋势= 0.066，0.025，
In industrial workers, formaldehyde exposure has been associated with cancer of the nasal cavities, nasopharynx, prostate, lung, and pancreas; however, these associations are inconsistent and remain controversial. Animals exposed to formaldehyde show excesses of nasal cancer. In an extended follow-up of a large cohort of formaldehyde-exposed workers, the authors evaluated mortality from solid cancers (1,921 deaths) among 25,619 workers (865,708 person-years) employed in 10 US formaldehyde-producing or -using facilities through 1994. Exposure assessment included quantitative estimates of formaldehyde exposure. Standardized mortality ratios and relative risks were calculated. Compared with that for the US population, mortality from solid cancers was significantly lower than expected among subjects exposed and nonexposed to formaldehyde (standardized mortality ratios = 0.91 and 0.78, respectively). Relative risks for nasopharyngeal cancer (nine deaths) increased with average exposure intensity, cumulative exposure, highest peak exposure, and duration of exposure to formaldehyde (p-trend = 0.066, 0.025,