TAP off--tumors on.
TAP off--tumors on.
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DOI：
10.1016/s0167-5699(97)80026-6
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发表时间：
1997-06
期刊：
影响因子：
--
通讯作者：
Barbara Seliger;Barbara Seliger;Markus Maeurer;Markus Maeurer;Soldano Ferrone;Soldano Ferrone
中科院分区：
文献类型：
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作者：
Barbara Seliger;Barbara Seliger;Markus Maeurer;Markus Maeurer;Soldano Ferrone;Soldano Ferrone
t细胞定义的肿瘤相关抗原的分子特征为恶性疾病的细胞介导免疫治疗提供了靶点。这一策略的成功受到主要组织相容性复合体（MHC） I类分子的结构和功能异常的负面影响，这些分子为肿瘤细胞提供对t细胞介导的免疫识别的抗性。本文综述了MHC I类加工机制的生理学，并描述了该途径在恶性细胞中的缺陷。
The molecular characterization of T-cell-defined tumor-associated antigens has provided targets for cell-mediated immunotherapy for malignant diseases. The success of this strategy is negatively influenced by structural and functional abnormalities of major histocompatibility complex (MHC) class I molecules, which provide tumor cells with resistance to T-cell-mediated immune recognition. This article reviews the physiology of the MHC class I processing machinery and describes the deficiencies of this pathway in malignant cells.