FALSE POSITIVES IN FUNCTIONAL NEAR-INFRARED TOPOGRAPHY
FALSE POSITIVES IN FUNCTIONAL NEAR-INFRARED TOPOGRAPHY
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DOI：
10.1007/978-0-387-85998-9_46
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Elwell, Clare E.
中科院分区：
文献类型：
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作者：
Tachtsidis, Ilias;Leung, Terence S.;Elwell, Clare E.
功能颅脑近红外光谱技术(NIRS)已被广泛应用于研究脑功能激活时的血流动力学变化。这项技术利用氧合和脱氧血红蛋白([HBO(2)][HHb])在近红外区域的不同吸收光谱来测量皮质组织中氧合和血液动力学的变化。本研究的目的是使用光学地形图系统，在同时监测系统生理(平均血压、心率、头皮流量)的同时，生成在字谜解决过程中额叶皮质(FC)和运动皮质(MC)的血流动力学反应的地形图。研究对象为22名健康的年轻成年人。激活范式由4、6和8个字母的字谜组成。光学地形图系统的12个通道位于FC上方，12个通道位于MC上方。在这项任务中，12名受试者至少有一个系统变量发生了显著变化(p
Functional cranial near-infrared spectroscopy (NIRS) has been widely used to investigate the haemodynamic changes which occur in response to functional activation. The technique exploits the different absorption spectra of oxy- and deoxy-haemoglobin ([HbO(2)] [HHb]) in the near-infrared region to measure the changes in oxygenation and haemodynamics in the cortical tissue. The aim of this study was to use an optical topography system to produce topographic maps of the haemodynamic response of both frontal cortex (FC) and motor cortex (MC) during anagram solving while simultaneously monitoring the systemic physiology (mean blood pressure, heart rate, scalp flux). A total of 22 young healthy adults were Studied. The activation paradigm comprised of 4-, 6- and 8- letter anagrams. 12 channels of the optical topography system were positioned over the FC and 12 channels over the MC. During the task 12 subjects demonstrated a significant change in at least one systemic variable (p