Journal of Translational Medicine BioMed Central
Journal of Translational Medicine BioMed Central
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DOI：
10.1016/j.molliq.2021.116247
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发表时间：
2008
影响因子：
6
通讯作者：
中科院分区：
文献类型：
--
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本文采用两步可逆加成-断裂链转移（RAFT）聚合与蒸馏悬浮聚合（DPP）相结合的方法合成两性星星共聚物。我们已经使用臂优先的方法，其中聚[2-（二甲基氨基）乙基甲基丙烯酸酯]（PDMAEMA）臂已经以三种不同的分子量合成。然后，将PDMAEMA臂用作MAA的DPP中的macroRAFT试剂，制备了N，N '-亚甲基双丙烯酰胺（MBA）交联核。核磁共振（1H NMR），差示扫描量热法（DSC），凝胶渗透色谱法（GPC）已被用来确认合成的星星两性聚电解质的准确性。用动态光散射（DLS）和场发射扫描电镜（FE-SEM）研究了pH对PDMAEMA-星星-PMAA星星共聚物自组装行为的影响。用紫外-可见光谱研究了星星型两性聚电解质的浊点（浊度行为）。结果表明，通过改变pH值，可以得到不同大小的球形、棒状和蠕虫状结构。此外，阿霉素（DOX）的释放行为已被测试的星星聚两性电解质在不同的pH值。结果表明，pH = 1时释放量大于pH = 7时，DOX释放量较高。
Herein, polyampholyte star copolymers have been preparedviaa two-step reversible addition-fragmentation chain transfer (RAFT) polymerization combined with disstilation presipitation polymerization (DPP). We have used arm-first approch where poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) arms have been synthesized in three different molecular weights. Then, PDMAEMA arms have been used as macroRAFT agent in DPP of MAA to prepare crosslinked core byN,N'-methylenebisacrylamide (MBA). Nuclear magnetic resonance (1H NMR), differential scanning calorimetry (DSC), and gel permeation chromatography (GPC) have been used to confirm the accuracy of the synthesized star polyampholytes. The effect of pH on the self-assembly behavior of PDMAEMA-star-PMAA star copolymers has been investigated by dynamic light scattering (DLS) and field emission scanning electron microscopy (FE-SEM). Also the cloud point (turbididity behavior) of the star polyampholytes has been investigated by UV–vis spectroscopy. Result indicated that, morphologies containing spherical, rod-shaped, and worm-like structures with different sizes have been obtained by chenging pH value. Also, doxorobicin (DOX) release behavior has been exmined for star polyampholytes at disparate pH values. Results showed that release amount was higher at pH = 1 than that at pH = 7 with high amount of DOX release.