A special type of chromosome 1 abnormality in myelodysplastic syndrome patients: duplication 1q.
A special type of chromosome 1 abnormality in myelodysplastic syndrome patients: duplication 1q.
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骨髓增生异常综合征患者的一种特殊类型的 1 号染色体异常：1q 重复。
DOI：
10.1111/bjh.16643
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Aining Sun
中科院分区：
文献类型：
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作者：
Yan Yu;Tongtong Zhang;Zhao Zeng;Qinrong Wang;Yang Hong;Hongjie Shen;Depei Wu;Jinlan Pan;Suning Chen;Aining Sun
关键词：骨髓增生异常综合征；1号染色体异常；重复1 q;新一代测序骨髓增生异常综合征1号染色体异常复制新一代测序编辑：造血肿瘤患者常发现1号染色体多重异常。[[1],[3]，[5]]一个例子是1q12-23扩增子，其在多发性骨髓瘤和b细胞淋巴瘤中的存在与疾病进展和不良预后相关。[[2]，[4]]在我们对骨髓增生异常综合征（MDS）的研究中，我们发现1号染色体不稳定性在MDS患者中也很常见。109例1号染色体畸变MDS患者的中位总生存期（中位随访19个月）为34个月，与1105例无1号染色体畸变MDS患者的中位总生存期（OS）比较，差异无统计学意义。(A) dup （1q）和其他1号染色体异常MDS患者的总生存期（OS），(B)单独dup （1q）和单独- y核型异常MDS患者的总生存期（OS）。《英国血液学杂志》版权归Wiley-Blackwell所有，未经版权所有者明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考资料的原始出版版本以获取完整摘要。版权适用于所有摘要。
Keywords: myelodysplastic syndromes; chromosome 1 abnormalities; duplication 1q; next-generation sequencing EN myelodysplastic syndromes chromosome 1 abnormalities duplication 1q next-generation sequencing e218 e221 4 06/08/20 20200601 NES 200601 To the editor, Multiple abnormalities of chromosome 1 have frequently been found in patients with haematopoietic neoplasms.[[1],[3],[5]] An example is the 1q12-23 amplicon, the presence of which in multiple myeloma and B-cell lymphomas is correlated with disease progression and poor prognosis.[[2],[4]] During our studies on myelodysplastic syndromes (MDS), we observed that chromosome 1 instabilities were also commonly found in MDS patients. The median overall survival (OS) of 109 MDS patients with chromosome 1 aberrations (median follow-up, 19 months) was 34 months and there was no statistically significant difference from that of 1105 MDS patients without chromosome 1 aberrations.(A) Overall survival (OS) for MDS patients with dup (1q) and other chromosome 1 abnormalities,(B) OS for MDS patients with alone dup (1q) and alone-Y karyotype abnormality.[Extracted from the article]Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.