Effect of amino acid supplementation on muscle mass, strength and physical function in elderly
Effect of amino acid supplementation on muscle mass, strength and physical function in elderly
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DOI：
10.1016/j.clnu.2008.01.001
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发表时间：
2008-04-01
影响因子：
6.3
通讯作者：
Wolfe, Robert R.
中科院分区：
文献类型：
--
作者：
Borsheim, Elisabet;Bui, Quynh-Uyen T.;Wolfe, Robert R.
背景与目的：随着年龄的增长，肌肉质量、力量和功能逐渐下降。本研究的目的是确定是否定期摄入的营养补充剂含有必需氨基酸（EAA）+精氨酸可以扭转这些反应在老年subjects.Methods：12葡萄糖不耐症受试者（67.0 +/- 5.6（SD）年，7名女性，5名配偶）摄入11克的EAA +精氨酸，每天两次，两餐之间，为16周。饮食和活动未作其他修改。每四周测量一次瘦体重（DEXA）。在第0、8、12、16周进行最大腿部力量测试和功能测试。结果：瘦体重（LBM）在研究期间增加（p = 0.038）。在第12周，LBM的平均增加为1.14 +/- 0.36（SE）kg（p < 0.05 vs基线），而在第16周，增加为0.60 +/- 0.38 kg（NS vs基线）。基线时下肢力量测量评分（单个膝关节屈肌和伸肌的一次重复最大值之和，n = 10）为127.5 +/- 21.8 kg，研究期间平均增加22.2 +/- 6.1%（p < 0.001）。在通常的步态速度（p = 0.002）、定时5步测试（p = 0.007）和定时地板转移测试（p = 0.022）中也观察到改善。(c)2008年爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: With advancing age there is a gradual decline in muscle mass, strength and function. The aim of this study was to determine if regular intake of a nutritional supplement containing essential amino acids (EAA) + arginine could reverse these responses in elderly subjects.Methods: Twelve glucose intolerant subjects (67.0 +/- 5.6 (SD) years, 7 females, 5 mates) ingested 11 g of EAA + arginine two times a day, between meals for 16 weeks. Diet and activity were not otherwise modified. Lean body mass (DEXA) was measured every fourth week. Maximal leg strength was tested and functional tests were performed at week 0, 8, 12, and 16.Results: Lean body mass (LBM) increased during the study (p = 0.038). At week 12, the average increase in LBM was 1.14 +/- 0.36 (SE) kg (p < 0.05 vs baseline), whereas at week 16, the increase was 0.60 +/- 0.38 kg (NS vs baseline). The lower extremity strength measure score (sum of individual knee flexors and extensors' one repetition maximum, n = 10) was 127.5 +/- 21.8 kg at baseline, and average increase during the study was 22.2 +/- 6.1% (p < 0.001). Improvements were also observed in usual gait speed (p = 0.002), timed 5-step test (p = 0.007), and timed floor-transfer test (p = 0.022).Conclusion: Supplementation of the diet with EAA + arginine improves lean body mass, strength and physical function compared to baseline values in glucose intolerant elderly individuals. (c) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.