Effects of type IV phosphodiesterase inhibition on cardiac function in the presence and absence of catecholamines
Effects of type IV phosphodiesterase inhibition on cardiac function in the presence and absence of catecholamines
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DOI：
10.1097/00005344-199811000-00013
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发表时间：
1998-11-01
影响因子：
3
通讯作者：
Jackson, EK
中科院分区：
文献类型：
--
作者：
Herzer, WA;Thomas, NJ;Jackson, EK
Type IV phosphodiesterase (PDE4) inhibitors may be useful in several diseases in which catecholamine infusions are commonly used, including asthma, sepsis, and multiple organ failure. To determine whether type TV phosphodiesterase inhibitors alter baseline or catecholamine-induced changes in cardiac function or both, we examined the effects of Ro 20-1724 (PDE4 inhibitor) on several cardiac-performance parameters in the absence and presence of norepinephrine, epinephrine, isoproterenol, and dobutamine infusions (3, 1, 0.1, and 3 mu g/kg/min, respectively). Male Sprague-Dawley rats received either Ro 20-1724 (10 mu g/kg/min; n = 7) or vehicle (n = 6). After a left ventricular catheter was placed and connected to a heart-performance analyzer, each animal received each of the four catecholamines in randomized order (10 min per catecholamine with a 30-min washout period between infusions). In the absence of catecholamines, Ro 20-1724 significantly but mildly (i.e.,
