Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies
Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies
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DOI：
10.1038/sj.leu.2404689
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发表时间：
2007-06-01
期刊：
影响因子：
11.4
通讯作者：
Matthes, T.
中科院分区：
文献类型：
--
作者：
Ody, C.;Jungblut-Ruault, S.;Matthes, T.
幼稚B细胞向浆细胞或记忆细胞的分化发生在淋巴滤泡的生发中心（GCs）或通过GC和t细胞独立的途径。目前认为b细胞淋巴瘤与正常b细胞分化阶段相关，但几种b细胞淋巴瘤与这两种途径的确切相关性仍存在争议。在本报告中，我们描述了目前在内皮细胞细胞边界发现的连接粘附分子C (JAM-C)，作为一种新的b细胞标志物，在b细胞分化过程中表达受到严格调控。扁桃体中JAM-C的表达可以区分两种CD27 + B细胞亚群：JAM-C + GC B细胞和JAM-C非生发B细胞。JAM-C在不同b细胞淋巴瘤中的表达揭示了一种疾病特异性模式，并使JAM-C +淋巴增殖性综合征（慢性淋巴细胞白血病、套细胞淋巴瘤和滤泡性淋巴瘤）和JAM-C +淋巴增殖性综合征（毛细胞白血病、边缘区b细胞淋巴瘤）之间有了明确的区别。因此，我们建议JAM-C作为b细胞淋巴瘤诊断的新鉴定工具。
Differentiation of naive B cells into plasma cells or memory cells occurs in the germinal centers (GCs) of lymph follicles or alternatively via a GC- and T-cell-independent pathway. It is currently assumed that B-cell lymphomas correlate to normal B-cell differentiation stages, but the precise correlation of several B-cell lymphomas to these two pathways remains controversial. In the present report, we describe the junctional adhesion molecule C (JAM-C), currently identified at the cell cell border of endothelial cells, as a new B-cell marker with a tightly regulated expression during B-cell differentiation. Expression of JAM-C in tonsils allows distinction between two CD27 + B-cell subpopulations: JAM-C + GC B cells and JAM-C-non-germinal B cells. The expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C + lymphoproliferative syndromes (chronic lymphocytic leukemia, mantle cell lymphoma and follicular lymphoma) and JAM-C + ones (hairy cell leukemia, marginal zone B-cell lymphoma). Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis.