Apoptosis: Overview and signal transduction pathways
Apoptosis: Overview and signal transduction pathways
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DOI：
10.1089/neu.2000.17.801
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发表时间：
2000-10-01
影响因子：
4.2
通讯作者：
Bredesen, DE
中科院分区：
文献类型：
--
作者：
Bredesen, DE
细胞凋亡是由固有的细胞自杀程序驱动的一种细胞死亡形式，细胞凋亡和其他形式的程序性细胞死亡在神经发育、维持和疾病状态中的作用日益被认识和定义，针对凋亡程序的治疗在神经退行性疾病、血管疾病和创伤性中枢神经系统损伤的动物模型中至少已经取得了一定程度的成功。本文描述了介导细胞凋亡的信号转导途径，广义地说，细胞凋亡激活的内在和外在途径可以区分开来，正如这两者之间的相互作用，这些途径汇聚在被称为CAPase(半胱氨酰天冬氨酸蛋白酶)的蛋白水解酶系统上，而存在多聚体、激活、放大或抑制caspase的调节剂，激活的caspase是凋亡程序的执行者，并通过裂解特定的细胞底物来执行这一功能，调节这一过程有望成为神经创伤的一种治疗方法。
Apoptosis is a form of cell death that is driven by an intrinsic cellular suicide program, The roles of apoptosis and other forms of programmed cell death in neural development, maintenance, and disease states are increasingly being recognized and defined, Therapies directed at the apoptotic program have seen at least some degree of success in animal models of neurodegenerative disease, vascular disease, and traumatic CNS injury, This article describes the signal transduction pathways that mediate apoptosis, Broadly speaking, intrinsic and extrinsic pathways for apoptosis activation may be distinguished, as can be cross-talk between these two, These pathways converge on a system of proteases referred to as "capases" (cysteinyl aspartic proteinases), and modulators exist that multimerize, activate, amplify, or inhibit caspases, Activated caspases are the executioners of the apoptotic program, and carry out this function by cleaving specific cellular substrates, Modulation of this process holds promise as a therapeutic approach in neurotrauma.