Angiogenesis, lymphangiogenesis and clinical implications. Preface.
Angiogenesis, lymphangiogenesis and clinical implications. Preface.
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DOI：
10.1159/000352074
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
G. Marone;F. Granata
中科院分区：
文献类型：
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作者：
G. Marone;F. Granata
血管生成，即新血管的形成，对于胚胎和产后发育、伤口修复和生殖功能等生理过程至关重要。血管生成在肿瘤生长以及多种自身免疫性疾病和过敏性疾病中发挥着重要作用。淋巴管生成（新淋巴管的形成）对于肿瘤生长、转移形成和慢性炎症性疾病也很重要。 Judah Folkman是血管生成研究的先驱，他首先提出巨噬细胞和肥大细胞可能是血管生成因子的相关来源。从那时起，人们付出了大量努力来阐明免疫细胞在调节血管生成和淋巴管生成中的作用。现在有令人信服的证据表明先天性和适应性免疫系统的几个组成部分与炎症和肿瘤性血管生成和淋巴管生成有关。本卷中的文章探讨了一种新出现的、有趣的可能性，即免疫细胞既是血管生成因子又是血管生成因子的靶标。因此，免疫系统细胞可能通过表达几种血管生成因子及其受体和共受体在炎症和肿瘤性血管生成/淋巴管生成中发挥作用。本卷中的重要新发现将引起血管生物学家、基础和临床免疫学家、肿瘤学家以及过敏和免疫疾病专家的特别兴趣。
Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.