Sleep duration regularity, but not sleep duration, is associated with microvascular function in college students
Sleep duration regularity, but not sleep duration, is associated with microvascular function in college students
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DOI：
10.1093/sleep/zsaa175
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发表时间：
2021-02-01
期刊：
影响因子：
5.6
通讯作者：
Witman, Melissa A. H.
中科院分区：
文献类型：
--
作者：
Hoopes, Elissa K.;Berube, Felicia R.;Witman, Melissa A. H.
研究目的：血管功能障碍是一种假想的机制，将不良的睡眠习惯与心血管疾病(CVD)的发病率增加联系起来。然而，与自由生活睡眠时间和睡眠规律性相关的血管分布还没有得到很好的阐明，特别是在年轻人中。因此，本研究旨在评估青年大学生平均睡眠时间、睡眠时间规律性与周围血管功能的关系。方法：51名健康本科生(20+/-1岁)完成了14天的24小时腕部活动及随后的血管评估。大血管功能测定采用肱动脉血流介导扩张法(FMD)，微血管功能测定采用被动腿部运动(PLM)。结果：平均睡眠时间与FMD和PLM无关。相反，更不规则的睡眠时间(14天睡眠时间标准差[SD])与PLM引起的充血的所有三个指标(腿部血流量峰值[LBF]，p=0.01；LBF从基线到峰值的变化，p<；0.01；LBF曲线下面积，p<；0.01)都是不利的关联，并且在调整了性别、体重指数、血压、体力活动、酒精和咖啡因摄入量以及睡眠时间的回归模型中仍然显著(均p<；0.05)。当使用中位数分裂将睡眠时长分为“低”和“高”时，睡眠时长高变异者的PLM反应比低变异性者低45%。结论：睡眠时长不规律与较差的微血管功能有关，早在成年初期。这些发现支持了越来越多的证据表明，不规律的睡眠模式可能是心血管疾病的一个独立和可改变的风险因素。
Study Objectives: Vascular dysfunction is a hypothesized mechanism linking poor sleep habits to an increased incidence of cardiovascular diseases (CVDs). However, the vascular profile associated with free-living sleep duration and sleep regularity has not been well elucidated, particularly in young adults. Thus, this study aimed to evaluate the associations between mean sleep duration, regularity in sleep duration, and peripheral vascular function in young adult college students.Methods: Fifty-one healthy undergraduate students (20 +/- 1 years) completed 14 days of 24-hour wrist actigraphy and subsequent vascular assessments. Macrovascular function was measured using brachial artery flow-mediated dilation (FMD) while microvascular function was measured via passive leg movement (PLM).Results: Mean sleep duration was unrelated to FMD and PLM. Conversely, more irregular sleep duration (14-day sleep duration standard deviation [SD]) was unfavorably associated with all three measures of PLM-induced hyperemia (peak leg blood flow [LBF], p = 0.01; change in LBF from baseline to peak, p < 0.01; LBF area under the curve, p < 0.01), and remained significant in regression models which adjusted for sex, body mass index, blood pressure, physical activity, alcohol and caffeine consumption, and sleep duration (all p < 0.05). When using a median split to dichotomize "low" and "high" sleep duration SD groups, those demonstrating high variability in sleep duration exhibited similar to 45% lower PLM responses compared with those demonstrating low variability.Conclusions: Irregular sleep duration is associated with poorer microvascular function as early as young adulthood. These findings support the growing body of evidence that irregular sleep patterns may be an independent and modifiable risk factor for CVD.