N-Acetylcysteine reduces early- and late-stage cocaine seeking without affecting cocaine taking in rats
N-Acetylcysteine reduces early- and late-stage cocaine seeking without affecting cocaine taking in rats
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DOI：
10.1111/j.1369-1600.2011.00330.x
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Belin, David
中科院分区：
文献类型：
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作者：
Murray, Jennifer E.;Everitt, Barry J.;Belin, David
n -乙酰半胱氨酸（NAC）通过对脑谷氨酸稳态的影响被认为在药物成瘾的治疗中具有潜在的治疗潜力。本研究表明，NAC治疗导致可卡因寻求在获得和维持可卡因寻求行为的早期和后期阶段呈剂量依赖性减少，同时证实它对可卡因强化没有影响。结果表明，NAC能够显著降低成瘾早期和晚期寻求可卡因的倾向，并与先前的工作结合起来，表明在预防复发方面具有重大潜力。
N-acetylcysteine (NAC) has been suggested to have therapeutic potential in the treatment of drug addiction through its effects on brain glutamate homeostasis. Here we show that NAC treatment resulted in dose-dependent reductions in cocaine seeking at both early and late stages of acquisition and maintenance of cocaine-seeking behavior, while confirming it had no effect on cocaine reinforcement. The results indicate that NAC is able to significantly diminish the propensity to seek cocaine early and late in the development of addiction and, taken together with previous work, indicates significant potential in relapse prevention.