Collateral reinnervation by the superior laryngeal nerve after recurrent laryngeal nerve injury
Collateral reinnervation by the superior laryngeal nerve after recurrent laryngeal nerve injury
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DOI：
10.1002/mus.21124
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发表时间：
2008-10-01
期刊：
影响因子：
3.4
通讯作者：
Mattsson, Per
中科院分区：
文献类型：
--
作者：
Hydman, Jonas;Mattsson, Per
本研究探讨完整的喉上神经（SLN）在喉返神经（RLN）损伤后喉肌环杓后肌（PCA）的再神经支配过程中的作用。利用成年大鼠慢性RLN损伤模型，采用逆行双示踪技术结合肌肉切片电生理和免疫组化评价PCA再神经的重建。结果表明，即使在未损伤的系统中，PCA也受到双喉神经的双重神经支配。功能上重要的侧支神经再生源于RLN损伤后完整的SLN纤维，主要是由于肌内发芽而不是通过募集更多的运动神经元。这在选择RLN损伤患者的手术和/或药物治疗时可能很重要。
This study investigates the role of the intact superior laryngeal nerve (SLN) in the reinnervation process of one of the laryngeal muscles, the posterior cricoarytenoid muscle (PCA), following recurrent laryngeal nerve (RLN) injury. Using a chronic RLN injury model in the adult rat, PCA reinnervation was assessed by retrograde double-tracing techniques in combination with electrophysiology and immunohistochemistry of muscle sections. The results demonstrate that the PCA receives dual innervation from both laryngeal nerves even in the uninjured system. Functionally significant collateral reinnervation originates from intact SLN fibers following RLN injury, mainly due to intramuscular sprouting rather than by recruitment of more motor neurons. This may be important when choosing surgical and/or medical treatment for patients with RLN injury.