Temperature-sensitive dendritic micelles
Temperature-sensitive dendritic micelles
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DOI：
10.1021/ja054542y
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发表时间：
2005-10-26
影响因子：
15
通讯作者：
Thayumanavan, S
中科院分区：
文献类型：
--
作者：
Aathimanikandan, SV;Savariar, EN;Thayumanavan, S
已经实现了三代的合成联芳基为基础的两亲性树枝状分子与电荷中性的五甘醇作为亲水部分和癸基链作为疏水部分。温度依赖特性的研究表明，这些树枝状分子表现出代数依赖的低临界溶解温度（LCST）。这种行为归因于亲水性五甘醇侧链的两亲性质和树枝状效应的组合。有趣的是，这种基于联芳基的支架还保持了在极性溶剂中形成胶束样组装体和在非极性溶剂中形成反胶束样组装体的能力。使用基于染料的微环境研究的树突状内部的极性进行了研究。用荧光光谱和动态光散射分析了胶束的聚集行为。这些组件的临界胶束浓度（CMC）进行了研究，使用荧光激发光谱的螯合客体分子，芘。
Syntheses up to three generations have been achieved of biaryl-based amphiphilic dendrons with a charge-neutral pentaethylene glycol as the hydrophilic part and a decyl chain as the hydrophobic part. Studies on the temperature-dependent characteristics revealed that these dendrons exhibit a generation-dependent lower critical solution temperature (LCST). This behavior is attributed to the combination of the amphipathic nature of the hydrophilic pentaethylene glycol side chain and dendritic effect. Interestingly, this biaryl-based scaffold also maintains the ability to form a micelle-like assembly in polar solvents and an inverted micelle-like assembly in apolar solvents. Polarity of the dendritic interior was investigated using dye-based microenvironment studies. The aggregation behavior of these micelles was analyzed by fluorescence spectroscopy and dynamic light scattering. Critical micelle concentrations (CMC) of these assemblies were investigated using fluorescence excitation spectra of the sequestered guest molecule, pyrene.