Vitamin E improves fibrinolytic activity in patients with coronary spastic angina
Vitamin E improves fibrinolytic activity in patients with coronary spastic angina
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DOI：
10.1016/j.thromres.2004.03.016
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发表时间：
2004-01-01
影响因子：
7.5
通讯作者：
Ogawa, H
中科院分区：
文献类型：
--
作者：
Miyamoto, S;Kawano, H;Ogawa, H
简介：纤溶系统作为抗血栓形成的防御机制具有重要作用。血浆中的净纤溶活性反映了组织型纤溶酶原激活物和纤溶酶原激活物抑制物（派）之间的平衡。派是决定总纤溶活性的主要因素。材料与方法：我们研究了口服维生素E（一种抗氧化剂）对冠状动脉痉挛性心绞痛患者纤溶活性和氧化应激的影响。40例冠状动脉痉挛性心绞痛患者随机分为维生素E组（α-生育酚醋酸酯，400 mg/d）和安慰剂组。派活性和硫氧还蛋白（氧化应激的标志物）水平在治疗前和治疗1个月结束时进行测量。结果如下：治疗前，痉挛型心绞痛患者血浆派活性和硫氧还蛋白水平较对照组（n = 17）明显升高（派活性水平：13.6 +/- 1.4对比7.6 +/-2.2IU/ml，p < 0.05，硫氧还蛋白水平：22.8 +/- 1.7对比16.0 +/-1.4ng/ml，p < 0.05）。在冠状动脉痉挛性心绞痛患者中，给予维生素E可降低派活性和硫氧还蛋白水平（派活性水平：14.7 +/- 1.7至7.5 +/- 1.6 IU/ml，p < 0.01，硫氧还蛋白水平：23.3 +/- 2.4至15.1 +/- 2.5 ng/ml，p < 0.01），而安慰剂对这些变量没有影响。结论：口服维生素E可改善纤溶活性，这种改善与氧化应激的降低有关。在无冠状动脉粥样硬化的情况下，给予维生素E可能是冠状动脉痉挛的有效辅助治疗。(C)2004 Elsevier Ltd.保留所有权利。
Introduction: The fibrinolytic system has a major role as a defense mechanism against thrombus formation. Net fibrinolytic activity in plasma reflects the balance between tissue-type plasminogen activator and plasminogen activator inhibitor (PAI). PAI is the main factor determining overall fibrinolytic activity. Materials and methods: We examined the effects of oral administration of vitamin E, an antioxidant, on fibrinolytic activity and oxidative stress in patients with coronary spastic angina. Forty patients with coronary spastic angina were randomly assigned into two treatment groups, either vitamin E group (alpha-tocopherot acetate, 400 mg/day) or placebo group by means of computerized system. PAI activity and thioredoxin, a marker of oxidative stress, levels were measured before and at the end of 1 month treatment. Results: Before treatment, the levels of PAI activity and thioredoxin were increased in patients with coronary spastic angina as compared with control subjects (n = 17) (PAI activity levels: 13.6 +/- 1.4 vs. 7.6 +/- 2.2 IU/ml, p < 0.05, thioredoxin levels: 22.8 +/- 1.7 vs. 16.0 +/- 1.4 ng/ml, p < 0.05). In patients with coronary spastic angina, administration of vitamin E decreased both PAI activity and thioredoxin levels (PAI activity levels: 14.7 +/- 1.7 to 7.5 +/- 1.6 IU/ml, p < 0.01, thioredoxin levels: 23.3 +/- 2.4 to 15.1 +/- 2.5 ng/ml, p < 0.01), whereas placebo had no effect on these variables. Conclusions: Oral administration of vitamin E improved fibrinolytic activity and the improvement was associated with a decrease in oxidative stress. Administration of vitamin E is possible to be an effective adjunct therapy of coronary spasm in the absence of coronary atherosclerosis. (C) 2004 Elsevier Ltd. All rights reserved.