Columnar architecture sculpted by GABA circuits in developing cat visual cortex
Columnar architecture sculpted by GABA circuits in developing cat visual cortex
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DOI：
10.1126/science.1091031
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发表时间：
2004-03-12
期刊：
影响因子：
56.9
通讯作者：
Stryker, MP
中科院分区：
文献类型：
--
作者：
Hensch, TK;Stryker, MP
哺乳动物的视觉皮层被组织成列。在这里，我们研究皮质的影响，通过改变内在的γ-氨基丁酸（GABA）介导的抑制与苯二氮卓类药物在猫的视觉传入。局部增强激动剂（安定）输注并没有扰乱视觉反应，但扩大列间距。反向激动剂（DMCM）产生相反的效果。因此，皮质内抑制电路的形状传入丘脑乔木的几何形状，这表明皮质柱状结构依赖于神经元的活动。
The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic gamma-aminobutyric acid (GABA)-mediated inhibition with benzodiazepines. Local enhancement by agonist (diazepam) infusion did not perturb visual responsiveness, but did widen column spacing. An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity.