Behavioral activation for the treatment of atypical depression: a pilot open trial.
Behavioral activation for the treatment of atypical depression: a pilot open trial.
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行为激活治疗非典型抑郁症：试点公开试验。
DOI：
10.1177/0145445511405646
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发表时间：
2011
影响因子：
2.3
通讯作者：
Miller,IvanW
中科院分区：
文献类型：
--
作者：
Weinstock,LaurenM;Munroe,MaryK;Miller,IvanW
尽管有证据表明非典型抑郁亚型的特点是发病年龄较早、情绪发作持续时间较长、症状严重程度较高以及对药物治疗的反应较差，但临床研究文献中对非典型抑郁症（AD）的心理社会干预相对被忽视。鉴于 AD 的症状特点是情绪反应性、精神运动减慢和人际交往退缩，作者认为行为激活 (BA) 干预可能特别适合这一人群。作为对这一假设的初步探索，本研究提供了 10 名 AD 门诊患者的初步结果数据，这些患者参加了为期 16 周的 BA 开放试点试验。总体而言，结果为 BA 治疗 AD 的可行性、可接受性和有效性提供了令人鼓舞的初步支持，显着减少了抑郁症状，并改善了功能障碍和 BA 水平。研究结果在 AD 现有治疗的背景下进行了讨论，并强调了未来治疗开发的领域。
Psychosocial interventions for atypical depression (AD) have been relatively ignored in the clinical research literature, despite evidence that the atypical subtype of major depression is marked by earlier age of onset, longer duration of mood episode, greater symptom severity, and poorer response to pharmacologic treatment. Given the symptom profile of AD, which is characterized by mood reactivity, psychomotor slowing, and interpersonal withdrawal, the authors argue that a behavioral activation (BA) intervention may be particularly well suited to this population. As an initial exploration of this hypothesis, the current study presents preliminary outcome data from 10 outpatients with AD who participated in an open pilot trial of BA over a 16-week period. Overall, results provide encouraging preliminary support for the feasibility, acceptability, and efficacy of BA for AD, with significant reductions in depressive symptoms and associated improvements in functional impairment and BA level. Study results are discussed in the context of existing treatments for AD, and areas for future treatment development are highlighted.