PROLIFERATIVE LESIONS OF THE MOUSE LUNG - PROGRESSION STUDIES IN STRAIN-A MICE
PROLIFERATIVE LESIONS OF THE MOUSE LUNG - PROGRESSION STUDIES IN STRAIN-A MICE
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DOI：
10.3109/01902149109064408
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发表时间：
1991-01-01
影响因子：
1.7
通讯作者：
MARONPOT, RR
中科院分区：
文献类型：
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作者：
FOLEY, JF;ANDERSON, MW;MARONPOT, RR
在用单剂量的氨基甲酸乙烯酯（60 mg/kg，i. p.）出生后6周。 在7、8、10、12或14个月时进行中期处死。 肺的恶性病变分为四类：增生、腺瘤、腺瘤内产生的癌和癌。 肉眼可见的表面肿瘤计数、组织学诊断和组织学病变的形态学测量用于评估进展。 经氨基甲酸乙烯酯处理的小鼠在所有时间点均显示平均表面肿瘤计数增加。 诊断评价表明，作为时间的函数，增生的相对频率降低，腺瘤的相对频率增加。 腺瘤的相对频率随后下降，而癌的相对频率增加。 在所有时间点，存在腺瘤内产生的癌。 随着时间的推移，腺瘤内产生的癌的数量减少，而“纯”癌的数量增加。 病变的形态学分析表明增生是小的，腺瘤大于增生，癌大于腺瘤和增生，这表明很少有腺瘤或癌出现从头。 总的来说，这些数据表明，在用乙烯基氨基甲酸酯处理的A/J小鼠中，大多数肺肿瘤以增生形式出现，进展为腺瘤，并最终导致癌。
The progression of pulmonary neoplasia was examined in strain A/J male mice treated with a single dose of vinyl carbamate (60 mg/kg, i.p.) 6 weeks after birth. Interim sacrifices were performed at 7, 8, 10, 12, or 14 months. Proliferative lesions of the lung were divided into four categories: hyperplasias, adenomas, carcinomas arising within adenomas, and carcinomas. Grossly visible surface tumor counts, histologic diagnoses, and morphometric measurements of histologic lesions were used to evaluate progression. Vinyl carbamate-treated mice showed increased mean surface tumor counts at all time points. Diagnostic evaluation suggested that as a function of time, the relative frequency of hyperplasias decreased and the relative frequency of adenomas increased. The relative frequency of adenomas subsequently decreased, whereas the relative frequency of carcinomas increased. At all time points, carcinomas arising within adenomas were present. As time progressed, the number of carcinomas arising within adenomas decreased, whereas the number of "pure" carcinomas increased. Morphometric analysis of lesions indicated hyperplasias to be small, that adenomas were larger than hyperplasias, and carcinomas were larger than adenomas and hyperplasias, suggesting that few adenomas or carcinomas arise de novo. Collectively, these data suggest that the majority of pulmonary tumors in A/J mice treated with vinyl carbamate arise as hyperplasias, progress to adenomas, and ultimately result in carcinomas.