Psychosocial Factors Influencing Parental Interest in Genomic Sequencing of Newborns
Psychosocial Factors Influencing Parental Interest in Genomic Sequencing of Newborns
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DOI：
10.1542/peds.2015-3731g
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发表时间：
2016-01-01
期刊：
影响因子：
8
通讯作者：
Green, Robert C.
中科院分区：
文献类型：
--
作者：
Waisbren, Susan E.;Weipert, Caroline M.;Green, Robert C.
背景技术背景：当新生儿的父母被告知在出生后立即获得新生儿基因组测序（GS）的假设可能性时，他们表达了极大的兴趣。本研究探讨了GS和人口统计学和社会心理变量之间的关联表示感兴趣的几个月后birth.METHODS：共有1096名父母参加了GS的新生儿出生后不久，他们的婴儿，出院前从产后地板的研究。在这些父母中，663人（60.5%）在2至28个月后完成了一项随访调查，询问他们对婴儿GS的兴趣，以及他们在怀孕、分娩和分娩期间是否收到了令人担忧的健康信息。他们还被管理了育儿压力指数。多元Logistic回归分析与新生儿GS的兴趣相关的因素。结果：76.1%的父母表示至少有一些感兴趣的GS。父母压力指数增加10点与对GS感兴趣的几率增加有关（比值比：1.15; 95%置信区间：1.01-1.32）。年龄，性别，种族，民族，婚姻状况，教育，焦虑，以及这是否是第一个生物学孩子与GS的兴趣没有显着相关。收到令人担忧的健康信息与GS更大的兴趣，但这并没有达到显着性（比值比：1.42; 95%置信区间：0.95-2.12）。结论：这个假设的调查研究表明，以前的经验，导致令人担忧的健康信息和父母的压力，他需要考虑当GS提供。目前正在进行的其他研究正在探索与真实的生活父母选择是否获得新生儿GS相关的因素。
BACKGROUND: When parents of newborns are presented with the hypothetical possibility of obtaining genomic sequencing (GS) for their newborn infants immediately after birth, they express substantial interest. This study examined associations between expressed interest in GS and demographic and psychosocial variables some months after birth.METHODS: A total of 1096 parents were enrolled in a study on GS of newborns shortly after the birth of their infants, before discharge from the postpartum floor. Of these parents, 663 (60.5%) completed a follow-up survey 2 to 28 months later that queried their interest in GS for their infant and whether they received worrisome health information during pregnancy, labor, and delivery. They were also administered the Parenting Stress Index. Multivariate logistic regression was used to examine factors associated with interest in GS of newborns.RESULTS: Of parents, 76.1% indicated at least some interest in GS. A 10-point increase on the Parenting Stress Index was associated with an increase in the odds of having some interest in GS (odds ratio: 1.15; 95% confidence interval: 1.01-1.32). Age, gender, race, ethnicity, marital status, education, anxiety, and whether this was the first biological child were not significantly associated with interest in GS. Receiving worrisome health information was associated with greater interest in GS but this did not reach significance (odds ratio: 1.42; 95% confidence interval: 0.95-2.12).CONCLUSION: This hypothetical survey study suggests that previous experiences leading to worrisome health information and parenting stress need to he considered when GS is offered. Additional research, currently underway, is exploring factors associated with real life parental choices around whether to obtain GS of their newborns.