A comparative study of graph-based, eikonal, and monodomain simulations for the estimation of cardiac activation times.
A comparative study of graph-based, eikonal, and monodomain simulations for the estimation of cardiac activation times.
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用于估计心脏激活时间的基于图、eikonal 和单域模拟的比较研究。
DOI：
10.1109/tbme.2012.2193398
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wallman M
中科院分区：
文献类型：
--
作者：
Wallman M
双域方程和单域方程是模拟心脏电生理行为的标准方程组。然而，详细双域/单域模拟的计算成本限制了它们在需要执行大量模拟的场景中的适用性（例如，参数估计）。在这项研究中，我们提出了一种基于图形的方法，它依赖于点到点的路径寻找，以最小的计算成本估计心脏组织中的单点的激活时间。为了验证我们的方法，激活时间进行比较，单域模拟结果的解剖学为基础的兔心室模型，结合现实的纤维取向和传导异质性。基于图的方法和单域结果之间的激活时间差异小于总激活时间的10%，并且当计算单点激活时间时，所提出的方法的计算性能快了几个数量级。这些结果表明，基于图形的方法非常适合于估计激活时间时，需要快速的性能证明了有限的损失的准确性。
The bidomain and monodomain equations are well established as the standard set of equations for the simulation of cardiac electrophysiological behavior. However, the computational cost of detailed bidomain/monodomain simulations limits their applicability in scenarios where a large number of simulations needs to be performed (e.g., parameter estimation). In this study, we present a graph-based method, which relies on point-to-point path finding to estimate activation times for single points in cardiac tissue with minimal computational costs. To validate our approach, activation times are compared to monodomain simulation results for an anatomically based rabbit ventricular model, incorporating realistic fiber orientation and conduction heterogeneities. Differences in activation times between the graph-based method and monodomain results are less than 10% of the total activation time, and computational performance is orders of magnitude faster with the proposed method when calculating activation times at single points. These results suggest that the graph-based method is well suited for estimating activation times when the need for fast performance justifies a limited loss of accuracy.