Effect of Buguzhi (Psoralea corylifolia fruit) Extract on Bone Formation
Effect of Buguzhi (Psoralea corylifolia fruit) Extract on Bone Formation
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DOI：
10.1002/ptr.3049
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发表时间：
2010-06-01
影响因子：
7.2
通讯作者：
Rabie, A. B. M.
中科院分区：
文献类型：
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作者：
Wong, R. W. K.;Rabie, A. B. M.
本研究的目的是比较补骨脂（补骨脂果实）提取物在胶原蛋白基质中产生的新骨量与体内产生的新骨量和胶原蛋白基质。在9只新西兰白色兔的顶骨中制造18个5 mm × 10 mm的骨缺损。用补骨脂提取物与胶原基质混合移植6个缺损。6个缺损仅用胶原基质移植（阳性对照），6个空白（阴性对照）。在第14天处死动物，解剖缺损并准备用于组织学评估。使用图像分析对100个切片（每组50个切片）进行新骨形成和骨细胞的定量分析。在胶原基质中用补骨脂提取物移植的缺损中，新骨的数量比用胶原基质移植的多275%。阴性对照组无骨形成。补骨脂组的骨细胞数量也显著高于阳性对照组。综上所述，补骨脂提取物在胶原基质中具有增加体内局部新骨形成的作用。补骨脂提取物在胶原蛋白基质中可用作骨移植材料。版权所有（C）2009约翰威利父子有限公司
The objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defects were grafted with Buguzhi extract mixed with collagen matrix. Six defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were sacrificed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells was made on 100 sections (50 sections for each group) using image analysis. A total of 275% more new bone was present in defects grafted with Buguzhi extract in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control group. The amount of bone cells was also significantly greater in the Buguzhi group than in the positive control group. To conclude, Buguzhi extract in collagen matrix has the effect of increasing new bone formation locally in vivo. Buguzhi extract in collagen matrix can be used as a bone graft material. Copyright (C) 2009 John Wiley & Sons, Ltd.