FOLLICULAR DEPLETION DURING THE MENOPAUSAL TRANSITION - EVIDENCE FOR ACCELERATED LOSS AND ULTIMATE EXHAUSTION
FOLLICULAR DEPLETION DURING THE MENOPAUSAL TRANSITION - EVIDENCE FOR ACCELERATED LOSS AND ULTIMATE EXHAUSTION
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DOI：
10.1210/jcem-65-6-1231
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发表时间：
1987-12-01
影响因子：
5.8
通讯作者：
NELSON, JF
中科院分区：
文献类型：
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作者：
RICHARDSON, SJ;SENIKAS, V;NELSON, JF
虽然绝经通常被认为是卵泡耗竭的结果，但卵泡数量与绝经过渡期的关系尚未得到明确的研究。我们对17名年龄在45-55岁的妇女进行了选择性全腹子宫切除术和输卵管卵巢切除术。这些妇女根据她们的月经史分为3组：1）规律性月经（n = 6），2）围绝经期（月经不规律; n = 7），和3）绝经后（距上次月经> 1年; n = 4）。3组的平均年龄相似。月经史由血浆激素水平和子宫内膜组织学证实。将每名妇女的一个卵巢连续切片，以确定卵泡数量。仍有规律排卵的妇女卵巢中原始卵泡的平均数量比围绝经期妇女高10倍[1392 . ±-.. 355（.+-. SEM）与142 . ±-. 72]。绝经后卵巢中几乎没有卵泡。将这些数据与其他人在年轻女性中获得的数据进行比较，表明卵泡在月经生活的最后十年急剧加速。这些结果支持了卵泡储备下降是围绝经期和绝经期过渡的直接原因的观点，并表明在生殖生命的最后阶段，卵泡消耗的速率和调节发生变化。
Although the menopause is generally considered to be the consequence of follicular exhaustion, the relationship between follicle number and the menopausal transition has not been explicity studied. We addressed this question in 17 women, aged 45-55 yr, who were undergoing elective total abdominal hysterectomy and salpingo-oophrectomy. The women were divided into 3 groups according to their menstrual history: 1) menstruating regularly (n = 6), 2) perimenopausal (irregular menses; n = 7), and 3) postmenopausal (> 1 yr since last menses; n = 4). The mean ages of the 3 groups were similar. Menstrual histories were confirmed by plasma hormone levels and endometrial histology. One ovary from each women was serially sectioned for determination of follicle numbers. The mean number of primordial follicles in the ovaries of women who were still menstruating regularly was 10-fold higher than that in perimenopausal women [1392 .+-. 355 (.+-. SEM) vs. 142 .+-. 72]. Follicles were virtually absent in the postmenopausal ovaries. Comparison of these data with those obtained by others in younger women suggests that follicular depletion accelerates dramatically in the last decade of menstrual life. These results support the view that declining follicular reserve is the immediate cause of both the perimenopausal and menopausal transitions, and indicate that the rate and, therefore, the regulation of follicular depletion change during the final phase of reproductive life.