Prevalence of Latent Tuberculosis Infection among Medical Students in South Korea.
Prevalence of Latent Tuberculosis Infection among Medical Students in South Korea.
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DOI：
10.4046/trd.2012.73.4.219
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发表时间：
2012-10
影响因子：
2.9
通讯作者：
Shim TS
中科院分区：
文献类型：
--
作者：
Jung DH;Jo KW;Shim TS
我们调查了韩国医学生中潜伏性结核感染（LTBI）的患病率。来自一所医学院的、在见习课程之前就读二年级或三年级的学生连续三年参加了这项研究。向每位参与者发放标准问卷，并进行结核菌素皮试 (TST)、QuantiFERON-TB GOLD 管内 (QFT-GIT) 测定和胸部 X 光检查。共有 153 名参与者参加了这项研究。受试者的平均年龄为 21.9±0.9 岁，其中 105 名（68.6%）为男性，132 名（86.3%）已接种卡介苗（BCG）。 4名学生（2.6%）在医疗实习期间有与结核病（TB）患者接触史。任何受试者的胸部X光片均未发现异常结果。在 153 名受试者中，23 名 (15.0%) 的 TST 检测呈阳性，8 名 (5.2%) 的 QFT-GIT 检测呈阳性。使用 kappa 系数确定两次测试之间的一致性为 0.34。在有与结核病患者接触史的四名学生中，只有一名学生两项测试均呈阳性，其他三名学生两项测试均呈阴性。在韩国，在实习课程之前的医学生中发现 LTBI 患病率较低。
We investigated the prevalence of latent tuberculosis infection (LTBI) among medical students in South Korea. Students from one medical school, who were in second- or third-year classes before clerkship course, were enrolled for three consecutive years in the study. A standard questionnaire was given to each participant, and tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (QFT-GIT) assay, and chest radiography were performed. A total of 153 participants were enrolled in the study. The mean age of the subjects was 21.9±0.9 years, 105 (68.6%) were male, and 132 (86.3%) had been vaccinated with Bacille Calmette-Guerin (BCG). Four students (2.6%) had a history of contact with tuberculosis (TB) patients during medical practice. No abnormal chest radiograph findings were found for any of the subjects. Of the 153 subjects, 23 (15.0%) tested positive for the TST, and 8 (5.2%) tested positive for the QFT-GIT. The agreement between the two tests was determined to be 0.34 using kappa coefficients. Of the four students who had a history of contact with TB patients, only one subject tested positive for both tests, and the other three students tested negative for both tests. A low prevalence of LTBI was found among medical students before clerkship course in South Korea.