Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles
Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles
复制标题
DOI：
10.1016/j.nutres.2016.11.010
复制
发表时间：
2016-12-01
影响因子：
4.5
通讯作者：
Wyka, Joanna
中科院分区：
文献类型：
--
作者：
Habanova, Marta;Saraiva, Jorge A.;Wyka, Joanna
心血管疾病（cvd）是导致死亡的主要原因，建议改变生活方式，包括改变饮食，以改善这种情况。在这项研究中，假设经常食用越桔对降低心血管疾病风险有有益的影响，通过改变人体健康指标，如降低低密度脂蛋白胆固醇（LDL-C）和甘油三酯（tg），增加高密度脂蛋白胆固醇（HDL-C）。在这项研究中，25名女性和11名男性每周食用3次150克冷冻越橘，持续6周。测量了人体测量参数、血压、血脂、葡萄糖、肝酶、肌酐、白蛋白、镁和抗自由基活性。除了女性的身体质量指数（P = 0.019）外，其他人体测量指标均无显著变化。食用越桔导致以下参数的降低：总胆固醇（P = 0.017）、LDL-C （P = 0.047）、TG （P = 0.001）、葡萄糖（P = 0.005）、白蛋白（P = 0.001）、γ -谷氨酰转移酶（P = 0.046）和HDL-C （P = 0.044）的正增加。此外，在男性中，总胆固醇（P = 0.004）、葡萄糖（P = 0.015）、白蛋白（P = 0.028）、天冬氨酸转氨酶（P = 0.012）、γ -谷氨酰转移酶（P = 0.013）和HDL-C (P = 0.009；在这一组中，LDL-C升高（P = 0.007）。对于男性和女性来说，其他参数的变化并不显著。因此，定期摄入越橘可以通过降低LDL-C/TG和增加HDL-C来降低心血管疾病的风险。(C) 2016 Elsevier Inc.版权所有。
Cardiovascular diseases (CVDs) are the leading causes of death, and lifestyle modification, including dietary changes, is recommended to improve this condition. In this study, regular consumption of bilberries was hypothesized to have beneficial effects on CVD risk reduction, by changes in human health indicators such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C). The research involved women (n = 25) and men (n = 11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks. Anthropometric parameters, blood pressure, lipid profile, glucose, liver enzymes, creatinine, albumin, magnesium, and antiradical activity were measured. Except for the body mass index of women (P =.019), no significant changes were found for anthropometric indicators. The consumption of bilberries led to a decrease in the following parameters: total cholesterol (P = .017), LDL-C (P = .0347), TG (P = .001), glucose (P = .005), albumin (P = .001), gamma-glutamyltransferase (P = .046), and a positive increase in HDL-C (P = .044). In men, additionally, favorable changes were observed in total cholesterol (P = .004), glucose (P = .015), albumin (P = .028), aspartate aminotransferase (P = .012), gamma-glutamyltransferase (P = .013), and HDL-C (P = .009; in this group, LDL-C increased IP = .007]). Changes in other parameters were not significant, for both women and men. Thus, the regular intake of bilberries can be important to reduce CVDs risk, by decreasing LDL-C/TG and increasing HDL-C. (C) 2016 Elsevier Inc. All rights reserved.