Hepatitis C virus infection in asymptomatic male volunteer blood donors in Karachi, Pakistan
Hepatitis C virus infection in asymptomatic male volunteer blood donors in Karachi, Pakistan
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DOI：
10.1111/j.1365-2893.2004.00518.x
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发表时间：
2004-11-01
影响因子：
2.5
通讯作者：
Hassan, F
中科院分区：
文献类型：
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作者：
Akhtar, S;Younus, M;Hassan, F
本研究的目的是评估巴基斯坦卡拉奇志愿者献血者中丙型肝炎病毒 (HCV) 反应者的比例，并确定与 HCV 感染相关的危险因素。 1998年1月1日至2002年12月31日期间，利用两个血库连续检测的献血量来评估HCV血清反应者献血者的比例。为了评估潜在的危险因素，实施了病例对照研究设计，以选择2001年10月15日至2002年3月15日之间的病例和对照。这些献血者的HCV总体血清阳性率为1.8%（6349/35 1309）。趋势分析显示，从 1998 年到 2002 年，HCV 血清阳性供者的比例显着（P < 0.001）线性增加。最终的多元逻辑回归模型显示，病例比对照组更有可能报告过去住院或接受过多次注射。当使用玻璃注射器进行治疗性注射时，病例中 HCV 血清阳性的调整后几率显着高于对照组，并且这种关系在由全科医生进行注射时比在医院环境中进行注射时更强。与对照组相比，病例更有可能报告与多个性伴侣发生性接触。侧重于已确定风险因素的初级预防计划可能有助于遏制丙型肝炎病毒感染在该社区和发展中国家其他类似环境中的传播。
The objectives of this study were to assess the proportion of hepatitis C virus (HCV) reactors and to identify risk factors associated with HCV infection in volunteer blood donors in Karachi, Pakistan. Between 1 January 1998 and 31 December 2002, consecutive blood donations tested at two blood banks were used to assess the proportion of HCV sero-reactors donors. To evaluate the potential risk factors, a case-control study design was implemented to select cases and controls between 15 October 2001 and 15 March 2002. The overall seroprevalence of HCV in these blood donors was 1.8% (6349/35 1309). Trend analysis revealed a significant (P < 0.001) linear increase in proportions of HCV-seropositive donors from 1998 to 2002. Final multivariate logistic regression model showed that the cases were more likely than controls to have reported past hospitalization or to have received multiple injections. When a glass syringe was used to give therapeutic injections, it increased the adjusted odds of being HCV seropositive significantly more among cases than in controls and this relationship was stronger when injection was given by general medical practitioner than if the injection was given in hospital setting. Cases were more likely than controls to have reported sexual contact with multiple sexual partners. Primary prevention programmes focused on identified risk factors might help to curtail the spread of HCV infection in this community and in other similar settings in developing countries.