THE EFFECTS OF MODERATE EXERCISE TRAINING ON NATURAL-KILLER-CELLS AND ACUTE UPPER RESPIRATORY-TRACT INFECTIONS
THE EFFECTS OF MODERATE EXERCISE TRAINING ON NATURAL-KILLER-CELLS AND ACUTE UPPER RESPIRATORY-TRACT INFECTIONS
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DOI：
10.1055/s-2007-1024839
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发表时间：
1990-12-01
影响因子：
2.5
通讯作者：
ARABATZIS, K
中科院分区：
文献类型：
--
作者：
NIEMAN, DC;NEHLSENCANNARELLA, SL;ARABATZIS, K
对36名轻度肥胖、久坐的女性进行了一项为期15周的随机对照运动训练（ET）研究（每周5次，每次45分钟，以60%的心率储备进行快走），以调查心肺适能改善、自然杀伤（NK）细胞数量和活性变化与急性上呼吸道感染（URI）发病率之间的关系。本研究采用2（运动组和非运动组）× 3（基线、6周和15周测试阶段）析因设计进行，数据采用重复测量ANOVA进行分析。通过CD 16和Leu-19单克隆抗体测量，由于ET，NK细胞数量没有发生显著变化。ET对NK细胞活性有显著影响（E：T 50：1），尤其是在最初的6周期间[F（2，68）= 12.34，p< 0.001]。使用每个受试者的每日日志数据，发现运动组的URI症状天数/事件明显少于非运动组（分别为3.6 ± 0.7和7.0 ± 1.4天，？= 0.049）。心肺适应性的改善与URI症状天数/事件的减少显著相关（r= 0.37，？= 0.99）。0.025）和NK细胞活性从基线至6周而非15周的变化（r= 0.35，p= 0.036）。总之，与随机、久坐对照组相比，中度ET与6周（而非15周）后NK细胞活性升高相关，并且与URI代谢降低相关。
A randomly controlled 15-wk exercise training (ET) study (five 45-min sessions/wk, brisk walking at 60% heart rate reserve) with a group of 36 mildly obese, sedentary women was conducted to investigate the relationship between improvement in cardiorespiratory fitness, changes in natural killer (NK) cell number and activity, and acute upper respiratory tract infection (URI) symptomatology. The study was conducted using a 2 (exercise and nonexercise groups)× 3 (baseline, 6-, and 15-wk testing sessions) factorial design, with data analyzed using repeated measures ANOVA. No significant change in NK cell number occurred as a result of ET as measured by the CD 16 and Leu-19 monoclonal antibodies. ET did have a significant effect on NK cell activity (E: T 50: 1) especially during the initial 6-wk period [F (2, 68)= 12.34, p< 0.001]. Using data from daily logs kept by each subject, the exercise group was found to have significantly fewer URI symptom days/incident than the nonexercise group (3.6+ 0.7 vs 7.0+ 1.4 days, respectively,?= 0.049). Improvement in cardiorespiratory fitness was correlated significantly with a reduction in URI symptom days/incident (r= 0.37,?= 0.025) and a change in NK cell activity from baseline to six but not 15 wks (r= 0.35, p= 0.036). In summary, moderate ET is associated with elevated NK cell activity after six but not 15 weeks, and reduced URI symptomatology in comparison to a randomized, sedentary control group.