Pathological Amygdala Activation During Working Memory Performance: Evidence for a Pathophysiological Trait Marker in Bipolar Affective Disorder
Pathological Amygdala Activation During Working Memory Performance: Evidence for a Pathophysiological Trait Marker in Bipolar Affective Disorder
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DOI：
10.1002/hbm.20849
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发表时间：
2010-01-01
影响因子：
4.8
通讯作者：
Rietschel, Marcella
中科院分区：
文献类型：
--
作者：
Gruber, Oliver;Tost, Heike;Rietschel, Marcella
最近的证据表明，赤字的工作记忆可能是一个有前途的神经认知内表型的双相情感障碍。然而，我们对这些缺陷的神经生物学相关性知之甚少。这项研究的目的是确定双相情感障碍在涉及工作记忆的神经回路中可能的病理生理特征标记。功能磁共振成像进行了18个正常的双相情感障碍患者和IS匹配的健康志愿者使用两个电路特定的实验任务，建立了以前的系统性神经成像研究的工作记忆。心境正常的双相情感障碍患者和健康对照组都表现出与工作记忆相关的脑激活，这与之前在健康受试者中进行的可比神经影像学研究的结果高度一致。虽然双相情感障碍患者的大脑激活模式完全保留，但只有患者在发音复述任务中表现出右侧杏仁核的激活。在同一任务中，患者右侧额叶和顶叶内皮层以及右侧小脑的功能激活显著增强。这些研究结果表明，右杏仁核的病理激活正常的双相情感障碍患者在执行特定电路的工作记忆任务（发音排练）。这种病理生理学异常似乎是双相情感障碍的一个特征标记，即使在正常情绪状态下也可以观察到，并且似乎在很大程度上独立于任务表现和药物治疗。《脑地图》31：115-125，2010年。(C)2009威利-利斯公司
Recent evidence suggests that deficits of working memory may be a promising neurocognitive endophenotype of bipolar affective disorder. However, little is known about the neurobiological correlates of these deficits. The aim of this stud), was to determine possible pathophysiological trait markers of bipolar disorder in neural circuits involved in working memory. Functional magnetic resonance imaging was performed in 18 euthymic bipolar patients and IS matched healthy volunteers using two circuit-specific experimental tasks established by prior systematic neuroimaging Studies of working memory. Both euthymic bipolar patients and healthy controls showed working memory-related brain activations that were highly consistent with findings from previous comparable neuroimaging studies in healthy subjects. While these patterns of brain activation were completely preserved in the bipolar patients, only the patients exhibited activation of the right amygdala during the articulatory rehearsal task. in the same task, functional activation in right frontal and intraparietal cortex and in the right cerebellum was significantly enhanced in the patients. These findings indicate that the right amygdala is pathologically activated in euthymic bipolar patients during performance of a circuit-specific working memory task (articulatory rehearsal). This pathophysiological abnormality appears to be a trait marker in bipolar disorders that can be observed even in the euthymic state and that seems to be largely independent of task performance and medication. Hum Brain Mapp 31:115-125, 2010. (C) 2009 Wiley-Liss, Inc.