Increased monocytes and bands following a red blood cell transfusion
Increased monocytes and bands following a red blood cell transfusion
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DOI：
10.1038/jp.2015.153
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发表时间：
2016-01-01
影响因子：
2.9
通讯作者：
Paul, D. A.
中科院分区：
文献类型：
--
作者：
Ellefson, A. M.;Locke, R. G.;Paul, D. A.
目的：本研究的目的是分析输注红细胞后发生的白细胞变化，以确定新生儿的亚临床炎性反应。STUDY设计：对在重症监护托儿所接受红细胞输注的婴儿进行回顾性分析。采集输血前至输血后48h内的白细胞结果并进行分析。统计分析采用单因素方差分析、t检验、M ann-Whitney U检验、皮尔逊相关分析和多元线性回归分析。结果：输血后单核细胞数(P=0.02)和单核细胞数(P=0.035)明显增加。单核细胞数(P=0.46)和单核细胞条带数(P=0.56)在有无血培养组之间无明显差异。有或无脓毒症的早产儿单核细胞数差异无统计学意义(P=0.88)。结论：我们发现早产儿输血后48小时内单核细胞数和单核细胞条带数显著升高。我们的发现支持与输注红细胞有关的可能的促炎反应。
OBJECTIVE: The objective of this study is to analyze the white blood cell changes that occur after a transfusion of red blood cells in order to identify a subclinical inflammatory response in neonates.STUDY DESIGN: Retrospective analysis of infants who received a red blood cell transfusion in an intensive care nursery. White blood cell results within 24 h pre- to 48 h post-transfusion were collected and analyzed. Statistical analysis included ANOVA, T-test, Mann-Whitney U test, Pearson's correlation and multivariable linear regression.RESULT: Monocytes (P = 0.02) and bands (P = 0.035) were increased post-transfusion. There were no differences in monocytes (P = 0.46) or bands (P = 0.56) between groups who did or did not have blood cultures obtained. There was no difference in monocytes between groups who did or did not have sepsis (P = 0.88).CONCLUSION: We identified an elevation in monocytes and bands in the 48 h following a transfusion in premature infants. Our findings support a possible pro-inflammatory response related to transfusion of red blood cells.