Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method
Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method
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DOI：
10.1016/s0927-7757(00)00825-6
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发表时间：
2001-06-30
影响因子：
5.2
通讯作者：
Kim, JH
中科院分区：
文献类型：
--
作者：
Kwon, HY;Lee, JY;Kim, JH
采用凝胶扩散法制备了载雌激素的可生物降解高分子载体--聚（D，L-丙交酯-乙交酯）（PLGA）纳米微粒。选择雌激素作为模型药物。制备方法包括将聚合物和药物的溶液在含有稳定剂的水相中乳化，预先饱和，然后加入过量的水。研究了工艺参数对纳米颗粒平均粒径的影响。结果表明，稳定剂的种类和浓度、匀化速度、聚合物浓度决定了PLGA纳米粒的粒径。特别是当使用双十二烷基二甲基溴化铵（DMAB）作为稳定剂时，获得了小于100 nm的含雌激素的纳米颗粒。(C)2001 Elsevier Science B. V.保留所有权利。
Nano-sized poly (D,L lactide-co-glycolide) (PLGA) particles, widely used as a biodegradable polymeric carrier, containing estrogen were prepared employing emulsification-diffusion method. Estrogen was chosen as a model drug. The preparation method consists of emulsifying a solution of polymer and drug in the aqueous phase containing stabilizer, previously saturated, followed by adding excess water. Influence of process variables on the mean particle size of nanoparticles has been studied. It was clarified that the type and concentrations of stabilizer, homogenizer speed, polymer concentration determined the size of PLGA nanoparticles. Especially when didodecyl dimethyl ammonium bromide (DMAB) was used as a stabilizer, estrogen containing nanoparticles of smaller than 100 nm was obtained. (C) 2001 Elsevier Science B.V. All rights reserved.