VAV1 represses E-cadherin expression through the transactivation of Snail and Slug: a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial ovarian cancer
VAV1 represses E-cadherin expression through the transactivation of Snail and Slug: a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial ovarian cancer
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DOI：
10.1016/j.trsl.2013.06.005
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发表时间：
2013-09-01
影响因子：
7.8
通讯作者：
Nishimura, Ryuichiro
中科院分区：
文献类型：
--
作者：
Wakahashi, Senn;Sudo, Tamotsu;Nishimura, Ryuichiro
卵巢癌是西方世界最致命的妇科恶性肿瘤。虽然早期卵巢癌患者通常预后良好，但大约20%-30%的患者会死于该病，5年复发率为25%-45%，凸显了改进检测和治疗的必要性。我们研究了 VAV1 的作用，VAV1 是一种具有鸟嘌呤核苷酸交换因子活性的蛋白质，它与早期卵巢癌（国际妇产科 (FIGO) I 期和 II 期）患者的生存相关。我们分析了来自原发性上皮性卵巢癌患者的 88 个样本，这些样本被分为FIGO I 期和II 期（n = 46）以及III 和IV 期（n = 42）。预后分析显示，VAV1 表达上调与早期上皮性卵巢癌患者的不良预后显着相关（P
Ovarian cancer is the most lethal gynecological malignancy in the western world. Although patients with early-stage ovarian cancer generally have a good prognosis, approximately 20%-30% of patients will die of the disease, and 5-year recurrence rates are 25%-45%, highlighting the need for improved detection and treatment. We investigated the role of VAV1, a protein with guanine nucleotide exchange factor activity, which is associated with survival in patients with early-stage ovarian cancer (International of Obstetrics and Gynecology (FIGO) stages I and II). We analyzed 88 samples from patients with primary epithelial ovarian cancer, which were divided into FIGO stages I and II (n = 46), and III and IV (n = 42). Prognostic analysis revealed that upregulated VAV1 expression correlated significantly with poor prognosis in patients with early-stage epithelial ovarian cancer (P