Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression
Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression
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DOI：
10.1615/critrevimmunol.2014009988
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发表时间：
2014-01-01
影响因子：
1.3
通讯作者：
Ishimaru, Naozumi
中科院分区：
文献类型：
--
作者：
Arakaki, Rieko;Yamada, Akiko;Ishimaru, Naozumi
激活诱导T细胞死亡（AICD）是一种调节外周免疫系统的过程。T细胞的命运是由来自各种刺激的许多信号控制的，如抗原、细胞因子和趋化因子。在健康人体内，过度激活或自身反应性T细胞是有害的，为了维持免疫系统，它们会被清除。Fas/ fasl介导的细胞凋亡在T细胞中的AICD是由几个信号分子从生到死的转换触发的。Fas或FasL表达的控制或分布在很大程度上影响T细胞的AICD。虽然自身免疫性疾病被认为是由多种因素诱导的，但Fas/ fasl介导的细胞凋亡导致AICD的免疫系统受损可导致自身免疫的发生或发展。基于已发表的报道，本文综述了人类和动物模型中Fas/ fasl介导的细胞凋亡参与T细胞AICD的调控机制以及AICD与自身免疫之间的关系。
Activation-induced cell death (AICD) of T cells is a process for regulating the peripheral immune system. The fate of a T cell is controlled by numerous signals derived from various stimuli, such as antigens, cytokines, and chemokines. In healthy humans, overactivated or autoreactive T cells are harmful and are eliminated to maintain the immune system. AICD in T cells by Fas/FasL-mediated apoptosis is triggered by the switch from life to death through several signaling molecules. The control or distribution of Fas or FasL expression largely affects AICD of T cells. Although autoimmune diseases are considered to be induced by multiple factors, an impaired immune system with AICD by Fas/FasL-mediated apoptosis leads to the onset or development of autoimmunity. Based on published reports, this review describes the regulatory mechanisms involved in AICD of T cells by Fas/FasL-mediated apoptosis and the associations between AICD and autoimmunity in humans and animal models.