Obtaining continuous BrAC/BAC estimates in the field: A hybrid system integrating transdermal alcohol biosensor, Intellidrink smartphone app, and BrAC Estimator software tools
Obtaining continuous BrAC/BAC estimates in the field: A hybrid system integrating transdermal alcohol biosensor, Intellidrink smartphone app, and BrAC Estimator software tools
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DOI：
10.1016/j.addbeh.2017.11.038
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发表时间：
2018-08-01
影响因子：
4.4
通讯作者：
Rosen, I. Gary
中科院分区：
文献类型：
--
作者：
Luczak, Susan E.;Hawkins, Ashley L.;Rosen, I. Gary
生物传感器已被开发用于测量经皮酒精浓度（TAC），但由于个体、饮酒事件和设备之间的TAC发生变化，因此难以将TAC转换为血液/呼吸酒精浓度（BAC/BrAC）的可解释指数。我们开发了数学模型和BrAC Estimate软件，用于校准TAC并将其转换为可量化的BrAC估计值（eBrAC）。用于确定佩戴特定设备的特定个体的个性化参数的校准协议需要同时获得BrAC和TAC测量值的饮用会话。该校准方案最初是在实验室中进行的，呼吸分析仪用于产生BrAC数据。在这里，我们开发并测试了一种替代校准方案，使用智能手机应用程序Intellidrink在现场收集的饮酒日记数据来生成BrAC校准数据。我们比较了BrAC Estimate软件的结果，11个饮酒事件收集的专家用户时，使用智能饮料与呼吸分析仪测量作为BrAC校准数据。反转相结果表明，与呼吸分析仪校准方案相比，Intellidrink校准方案产生了类似的eBrAC曲线，并将eBrAC峰值捕获到0.0003%以内，将eBrAC峰值时间捕获到18 min以内，将eBrAC曲线下面积捕获到0.025%酒精-小时以内。这项研究提供的证据表明，在BrAC Estimate软件校准程序中，可以使用饮酒日记数据代替呼吸分析仪数据，这可以减少参与者和研究人员的负担，并将潜在的软件用户库扩展到研究实验室饮酒参与者的研究人员之外。
Biosensors have been developed to measure transdermal alcohol concentration (TAC), but converting TAC into interpretable indices of blood/breath alcohol concentration (BAC/BrAC) is difficult because of variations that occur in TAC across individuals, drinking episodes, and devices. We have developed mathematical models and the BrAC Estimator software for calibrating and inverting TAC into quantifiable BrAC estimates (eBrAC). The calibration protocol to determine the individualized parameters for a specific individual wearing a specific device requires a drinking session in which BrAC and TAC measurements are obtained simultaneously. This calibration protocol was originally conducted in the laboratory with breath analyzers used to produce the BrAC data. Here we develop and test an alternative calibration protocol using drinking diary data collected in the field with the smartphone app Intellidrink to produce the BrAC calibration data. We compared BrAC Estimator software results for 11 drinking episodes collected by an expert user when using Intellidrink versus breath analyzer measurements as BrAC calibration data. Inversion phase results indicated the Intellidrink calibration protocol produced similar eBrAC curves and captured peak eBrAC to within 0.0003%, time of peak eBrAC to within 18 min, and area under the eBrAC curve to within 0.025% alcohol-hours as the breath analyzer calibration protocol. This study provides evidence that drinking diary data can be used in place of breath analyzer data in the BrAC Estimator software calibration procedure, which can reduce participant and researcher burden and expand the potential software user pool beyond researchers studying participants who can drink in the laboratory.