Thiobarbituric acid reactive substances in patients with laryngeal cancer
Thiobarbituric acid reactive substances in patients with laryngeal cancer
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DOI：
10.1046/j.1365-2273.1999.00249.x
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发表时间：
1999-06-01
影响因子：
2.1
通讯作者：
El Kholy, NM
中科院分区：
文献类型：
--
作者：
Samir, M;El Kholy, NM
本研究的目的是检测30例喉癌患者体内脂质过氧化产物硫代巴比妥酸反应物质(TBARS)的水平，以反映喉癌患者的氧化状态。分别于手术前1天和术后3周用分光光度法测定泪液中硫代巴比妥酸(TBA)的含量，并与30例正常对照组进行比较。喉癌患者泪液含量明显高于对照组(18.4+/-3.13MU/L比7.75+/-1.9MU/L；P<；0.05)。泪液水平与T分期、N分期或分化程度无关。在喉癌患者中，吸烟者的泪水水平略高。喉癌手术前后的配对观察结果显示，喉癌手术后泪液水平明显升高。手术造成的组织损伤是这种上升的最可能的解释。在我们的患者中检测到的脂质过氧化状态改变可能与抗氧化剂状态不足有关。抗氧化剂在预防高危患者喉癌中的作用值得研究。
The purpose of this study was to measure the level of thiobarbituric acid reactive substances (TBARS), which are products of lipid peroxidation, as a reflection of oxidative status in 30 patients with laryngcal cancer. The TEARS were measured 1 day before surgery and 3 weeks after laryngcctomy compared to 30 normal control subjects by the thiobarbituric acid (TBA) test using spectrophotometry. The TEARS levels were significantly elevated in patients with laryngeal cancer compared to the controls (18.4 +/- 3.13 mu mol/l versus 7.75 +/- 1.9 mu mol/l; P < 0.05). There were no differences in the TEARS levels in relation to T staging, N staging, or degree of differentiation. Among patients with laryngeal cancer smokers had slightly higher TEARS levels. Comparison of the paired observations of laryngeal cancer larynx before and after operation revealed a significant rise in the TEARS levels after laryngectomy. Tissue damage resulting from surgery is the most probable explanation for this rise. The state of altered lipid peroxidation detected in our patients might be related to a deficient antioxidant status. The role of antioxidants in the prevention of laryngeal cancer among high risk patients is worth studying.