Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial
Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial
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DOI：
10.1590/1678-7757-2018-0564
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发表时间：
2019-01-01
影响因子：
2.7
通讯作者：
NIKAWA, Hiroki
中科院分区：
文献类型：
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作者：
Yuki, ODA;FURUTANI, Chiaki;NIKAWA, Hiroki
对智力残疾（ID）个体口腔健康的研究已经确定了包括牙周病高发在内的问题。使用益生菌治疗牙周病一直是大量研究的焦点，用鼠李糖乳杆菌L8020 （L8020酸奶）发酵的牛乳已被证明可以减少四种牙周病原体的口腔患病率。目的：本随机、双盲、安慰剂对照试验的目的是比较L8020酸奶（试验组）与安慰剂酸奶（安慰剂组）对23例ID患者乳头边缘附着（PMA）指数、牙龈指数（GI）和探入深度（PD）的影响。方法：所有患者被要求在早餐后饮用分配的酸奶90天。在开始饮用酸奶前（基线）、饮用后45天和90天以及停止饮用后30天评估PMA指数和GI评分以及pd。组间比较采用Student’st检验、Mann-Whitney U检验或Fisher’s exact检验，数据分析采用重复测量的混合效应模型。结果：试验组PMA指数评分下降幅度明显大于安慰剂组(p
Studies on the oral health of individuals with intellectual disability (ID) have identified problems that include a high prevalence of periodontal disease. The use of probiotics to treat periodontal disease has been the focus of considerable research, and bovine milk fermented with Lactobacillus rhamnosus L8020 (L8020 yogurt) has been shown to reduce the oral prevalence of four periodontal pathogens. Objective: The aim of this randomized, double-blind, placebo-controlled trial was to compare the effects of L8020 yogurt (test group) with those of placebo yogurt (placebo group) on the papillary-marginal-attached (PMA) index, gingival index (GI), and probing depth (PD) in 23 individuals with ID. Methodology: All patients were required to consume the allocated yogurt after breakfast for 90 days. PMA index and GI scores as well as PDs were assessed before the start of yogurt consumption (baseline), after 45 and 90 days of consumption, and 30 days after the cessation of consumption. Student's t-test, Mann-Whitney U test or Fisher's exact test was used for inter-group comparisons, and the mixed effect model of repeated measurements was used for data analysis. Results: The decrease in PMA index score was significantly greater in the test group than in the placebo group (p