Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol.
Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol.
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DOI：
10.3390/molecules23112827
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发表时间：
2018-10-31
期刊：
影响因子：
--
通讯作者：
Ahn KS
中科院分区：
文献类型：
--
作者：
Jung YY;Hwang ST;Sethi G;Fan L;Arfuso F;Ahn KS
法尼醇是一种无环倍半萜醇，主要存在于自然界各种植物精油中。据报道，它具有抗癌和抗炎作用，还能缓解过敏性哮喘、神经胶质瘤和水肿。在许多肿瘤细胞系中，法尼醇可以调节多种致瘤蛋白和/或调节多种信号转导级联反应。它还能诱导细胞凋亡，下调细胞增殖、血管生成和细胞存活。法尼醇通过调节Ras蛋白和活化B细胞活化的核因子kappa-轻链增强子，下调环氧化酶-2、诱导型一氧化氮合酶、肿瘤坏死因子α、白细胞介素-6等多种炎症介质的表达，发挥其抗炎/抗癌作用。在这篇综述中，我们描述了法尼醇治疗癌症和炎症性疾病的潜在作用机制。此外，这些发现支持了法尼醇作为一种潜在的药物在临床研究中的临床发展。
Farnesol, an acyclic sesquiterpene alcohol, is predominantly found in essential oils of various plants in nature. It has been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis, and edema. In numerous tumor cell lines, farnesol can modulate various tumorigenic proteins and/or modulates diverse signal transduction cascades. It can also induce apoptosis and downregulate cell proliferation, angiogenesis, and cell survival. To exert its anti-inflammatory/anti-oncogenic effects, farnesol can modulate Ras protein and nuclear factor kappa-light-chain-enhancer of activated B cells activation to downregulate the expression of various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin-6. In this review, we describe the potential mechanisms of action underlying the therapeutic effects of farnesol against cancers and inflammatory disorders. Furthermore, these findings support the clinical development of farnesol as a potential pharmacological agent in clinical studies.
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DOI：
10.1016/j.bbrc.2006.02.145
发表时间：
2006-04-28
影响因子：
3.1
作者：
Duncan, RE;Archer, MC
通讯作者：
Archer, MC
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
4.3
作者：
Ishizaka, H;Yamada, H;Sasaki, K
通讯作者：
Sasaki, K
影响因子：
50.3
作者：
Carver BS;Chapinski C;Wongvipat J;Hieronymus H;Chen Y;Chandarlapaty S;Arora VK;Le C;Koutcher J;Scher H;Scardino PT;Rosen N;Sawyers CL
通讯作者：
Sawyers CL
影响因子：
11.2
作者：
Ahn, Kwang Seok;Sethi, Gautam;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.