CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions
CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions
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DOI：
10.1007/s004280100530
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发表时间：
2002-03-01
期刊：
影响因子：
3.5
通讯作者：
Moll, R
中科院分区：
文献类型：
--
作者：
Barth, PJ;Ebrahimsade, S;Moll, R
本研究旨在阐明乳腺良、恶性病变间质CD34(+)纤维细胞和平滑肌肌动蛋白(SMA)反应性肌成纤维细胞的分布是否存在差异。我们对31例导管癌和27例乳腺良性病变(导管增生、硬化性腺病、纤维腺瘤、叶状瘤)进行了研究，并比较了CD34(+)纤维细胞和SMA反应性肌成纤维细胞的分布。正常乳腺组织间质中含有CD34(+)成纤维细胞，而SMA反应性肌成纤维细胞缺失。所有良性乳腺病变均显示间质CD34(+)纤维细胞，少数病变(纤维腺瘤和叶状瘤)显示额外的SMA反应性肌成纤维细胞。在浸润性乳腺癌中，间质中没有CD34(+)纤维细胞，但可以检测到不同数量的间质SMA反应性肌成纤维细胞。在本研究的背景下，CD34(+)纤维细胞的丢失仅见于浸润性乳腺癌和导管原位癌，而SMA反应性肌成纤维细胞在不同的良性和恶性病变中被观察到。这些发现可能有助于区分乳腺良性病变(如硬化性腺病)和浸润性乳腺癌，并有助于表征与浸润性癌相关的间质重塑。
The present study was undertaken in order to elucidate the question of whether the distribution of stromal CD34(+) fibrocytes and smooth muscle actin (SMA)-reactive myofibroblasts differs between benign and malignant lesions of the breast. We investigated a total of 31 ductal carcinomas and 27 specimens with benign lesions of the breast (ductal hyperplasia, sclerosing adenosis, fibroadenoma, phyllodes tumor) and compared the distribution of CD34(+) fibrocytes and SMA-reactive myofibroblasts. The stroma of normal breast tissue contained CD34(+) fibrocytes, whereas SMA-reactive myofibroblasts were absent. All benign breast lesions exhibited stromal CD34(+) fibrocytes and few lesions (fibroadenomas and phyllodes tumor) showed additional SMA-reactive myofibroblasts. In invasive breast cancer the stroma was devoid of CD34(+) fibrocytes but a varying number of stromal SMA-reactive myofibroblasts was detectable. In the setting of the present study the loss of CD34(+) fibrocytes was specific for invasive breast cancer and ductal carcinoma in situ, whereas SMA-reactive myofibroblasts were observed in different benign and malignant lesions. These findings may be helpful tools in distinguishing benign breast lesions (e.g., sclerosing adenosis) from invasive breast cancer and in characterizing stromal remodeling associated with invasive cancer.