Valproic acid treated female Long-Evans rats are impaired on attentional set-shifting.
Valproic acid treated female Long-Evans rats are impaired on attentional set-shifting.
复制标题
丙戊酸治疗的雌性长evans大鼠的注意力转移会受到损害。
DOI：
10.1016/j.bbr.2020.112966
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发表时间：
2021-01-15
影响因子：
2.7
通讯作者：
Plakke B
中科院分区：
文献类型：
--
作者：
McKinnell ZE;Maze T;Ramos A;Challans B;Plakke B
Autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by social deficits, communication impairments, restrictive behaviors, and cognitive flexibility deficits. The valproic acid (VPA) model of autism has been widely used to examine changes in rodent behavior and neurobiology to better understand ASD. This study examined social and anxiety behavior as well as cognitive flexibility in VPA and control offspring. Results for social behavior were consistent with prior studies showing reduced sociability in VPA rats and increased self-grooming, which may be viewed as a repetitive behavior. VPA rats also had deficits in performing the set-shifting task, with female VPA rats demonstrating greater impairment compared to female control rats and male VPA rats. These results support the hypothesis that females diagnosed with ASD may suffer from different symptoms and present a unique behavioral profile compared to males with ASD. Female VPA rats were also less likely to form an attentional set; offering evidence that the VPA model of autism is encompassing executive function deficits similar to those observed in humans with ASD.
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影响因子：
4.7
作者：
Anshu, Kumari;Nair, Ajay Kumar;Laxmi, T. Rao
通讯作者：
Laxmi, T. Rao
影响因子：
2.7
作者：
Kerr, D. M.;Downey, L.;Roche, M.
通讯作者：
Roche, M.
影响因子：
3.4
作者：
Chase, E. Alexander;Tait, David S.;Brown, Verity J.
通讯作者：
Brown, Verity J.
影响因子：
4
作者：
Dean, JCS;Hailey, H;Little, J
通讯作者：
Little, J
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF