Quantitative Sensory Testing in adults with Autism Spectrum Disorders
Quantitative Sensory Testing in adults with Autism Spectrum Disorders
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DOI：
10.1007/s10803-017-3041-4
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发表时间：
2017-04-01
影响因子：
3.9
通讯作者：
Bingel, Ulrike
中科院分区：
文献类型：
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作者：
Fruendt, Odette;Grashorn, Wiebke;Bingel, Ulrike
在自闭症谱系障碍(ASD)患者中发现感觉知觉改变，可能与感觉知觉阈值异常有关。我们使用德国神经病理性疼痛研究网络的成熟、标准化的定量感觉测试(QST)方案，对13名ASD成年人和13名智商正常的匹配健康对照组进行了13项躯体感觉参数的调查，包括温度和触觉检测以及痛阈值。躯体感觉检测和痛觉阈值之间无组间差异。两名ASD患者表现出矛盾的热感，另外两名ASD患者表现出动态机械异常痛觉；躯体感觉特征在对照组中缺失。这些发现表明，ASD的躯体感觉改变可能是由复杂刺激整合的中枢机制决定的，而不是由外周功能障碍决定的。
Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds. Two ASD patients showed paradoxical heat sensations and another two ASD subjects presented dynamic mechanical allodynia; somatosensory features that were absent in controls. These findings suggest that central mechanisms during complex stimulus integration rather than peripheral dysfunctions probably determine somatosensory alterations in ASD.