Left posterior inferior parietal cortex causally supports the retrieval of action knowledge
Left posterior inferior parietal cortex causally supports the retrieval of action knowledge
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DOI：
10.1016/j.neuroimage.2020.117041
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发表时间：
2020-10-01
期刊：
影响因子：
5.7
通讯作者：
Hartwigsen, Gesa
中科院分区：
文献类型：
--
作者：
Kuhnke, Philipp;Beaupain, Marie C.;Hartwigsen, Gesa
概念知识是人类认知的核心。左后下顶叶（pIPL）是牵连的神经影像学研究作为一个多模态的枢纽，代表各种感知运动模态相关的概念知识。然而，左pIPL在概念处理中的因果作用仍不清楚。在这里，我们暂时中断左pIPL功能与经颅磁刺激（TMS），以探讨其因果关系的行动和声音知识的检索。我们比较了有效的TMS左pIPL与假TMS，而健康的参与者进行了三个不同的任务-词汇决策，动作判断和声音判断的话与行动和声音的高或低的关联。我们发现，pIPL-TMS选择性地损害行动的判断低声音低动作词。这是第一次，我们直接相关的TMS诱导电场的计算模拟的行为表现，这表明，更强的刺激左pIPL与较差的性能的行动，但不是健全的判断。这些结果表明，左pIPL因果地支持概念加工时，行动知识是任务相关的，不能由声音知识补偿。我们的研究结果表明，左pIPL专门用于检索动作知识，这挑战了左pIPL作为多模态概念中心的观点。
Conceptual knowledge is central to human cognition. The left posterior inferior parietal lobe (pIPL) is implicated by neuroimaging studies as a multimodal hub representing conceptual knowledge related to various perceptual-motor modalities. However, the causal role of left pIPL in conceptual processing remains unclear. Here, we transiently disrupted left pIPL function with transcranial magnetic stimulation (TMS) to probe its causal relevance for the retrieval of action and sound knowledge. We compared effective TMS over left pIPL with sham TMS, while healthy participants performed three different tasks-lexical decision, action judgment, and sound judgment-on words with a high or low association to actions and sounds. We found that pIPL-TMS selectively impaired action judgments on low sound-low action words. For the first time, we directly related computational simulations of the TMS-induced electrical field to behavioral performance, which revealed that stronger stimulation of left pIPL is associated with worse performance for action but not sound judgments. These results indicate that left pIPL causally supports conceptual processing when action knowledge is task-relevant and cannot be compensated by sound knowledge. Our findings suggest that left pIPL is specialized for the retrieval of action knowledge, challenging the view of left pIPL as a multimodal conceptual hub.