Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.
Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.
复制标题
患有良性和恶性乳腺疾病的女性术前二十四小时内分泌状况。
作者：
W. Malarkey;L. Schroeder;V. C. Stevens;A. James;R. Lanese
平均24小时生长激素，促黄体生成素，促卵泡激素，雌二醇和孕酮浓度术前确定的16名妇女良性乳腺肿块和17例乳腺癌患者与25个年龄和体重匹配的对照组中发现的水平相似。平均24小时睾酮水平，但是，显着升高的妇女乳腺癌评估在黄体期的周期和正常的绝经后乳腺癌妇女。此外，这些受试者的血清促甲状腺激素、甲状腺素、胆固醇和甘油三酯水平均正常。良性和恶性乳腺疾病组的血浆皮质醇和尿17-羟类固醇排泄量往往较高，可能反映了术前焦虑。因此，我们已经发现了正常浓度的各种内分泌和其他生物化学试剂，可以刺激乳腺组织生长和/或先前已报告在乳腺癌妇女中紊乱。
Mean 24-hr growth hormone, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone concentrations determined preoperatively in 16 women with benign breast masses and 17 patients with breast cancer were similar to those levels found in 25 age- and weight-matched control subjects. Mean 24-hr testosterone levels, however, were significantly elevated in women with breast cancer evaluated in the luteal phase of their cycles and were normal in postmenopausal breast cancer women. In addition, serum thyroid-stimulating hormone, thyroxine, cholesterol, and triglyceride levels were normal in these subjects. Plasma cortisols and urinary 17-hydroxysteroid excretion tended to be higher in both the benign and malignant breast disease group and probably reflected preoperative anxiety. Hence, we have found normal concentrations of a variety of endocrine and other biochemical agents that can stimulate breast tissue growth and/or have been previously reported to be disordered in women with breast cancer.