Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.
Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.
复制标题
减少尼古丁含量香烟和替代性尼古丁产品的使用：探索性试验。
DOI：
10.1111/add.13603
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发表时间：
2017-01
期刊：
影响因子：
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通讯作者：
al'Absi M
中科院分区：
文献类型：
--
作者：
Hatsukami DK;Luo X;Dick L;Kangkum M;Allen SS;Murphy SE;Hecht SS;Shields PG;al'Absi M
比较不愿意戒烟的吸烟者的替代尼古丁产品的使用、吸烟行为和烟草生物标志物暴露，这些吸烟者被随机分配到尼古丁含量正常（NNC）的香烟和尼古丁含量极低（VLNC）的香烟。随机、平行组8周研究，被分配到使用非卷烟燃烧和非燃烧烟草/尼古丁产品的VLNC （VLNC 1， N= 53）或使用非燃烧烟草/尼古丁产品的NNC （NNC， N=27）或仅使用非燃烧产品的VLNC （VLNC2， N=56）。对戒烟不感兴趣的吸烟者，平均（SD）年龄44（14）岁，每天吸烟16(7)支；女性占51%，白人占72%。在实验期间采取的措施包括：使用替代产品的比率，使用燃烧烟草的数量和戒断程度，以及烟草暴露生物标志物。VLNC组与NNC组相比，使用非可燃替代烟草/尼古丁产品的比例更高（比率比[RR]=2.18, 95% CI= 1.94, 2.46， RR=1.64, 95% CI=1.46, 1.85）， VLNC1组与VLNC2组相比（RR=1.33, 95% CI=1.23, 1.44），主要在VLNC2组中，生物标志物暴露减少（ps < 0.05）。在几乎所有的访问中，吸烟的燃烧产物较少（ps≤0.02），两种VLNC组的戒烟率都高于NNC组（VLNC1 vs NNC: RR = 9.96, 95% CI = 5.01, 19.81; VLNC2 vs NNC: RR = 11.23, 95% CI = 5.74, 21.97）。与继续使用普通尼古丁香烟相比，在8周内提供和使用尼古丁含量降低的香烟会导致更多的人使用替代烟草/尼古丁产品，吸烟率也会降低。
To compare use of alternative nicotine products, smoking behavior and tobacco biomarker exposure in smokers unwilling to quit who were randomly assigned to normal nicotine content (NNC) cigarettes, or very low nicotine content (VLNC) cigarettes. Randomized, parallel arm 8-week study with assignment to VLNC (VLNC 1, N =53) or NNC (NNC, N=27) with access to non-cigarette combusted and non-combusted tobacco/nicotine products or to VLNC with access to only non-combusted products (VLNC2; N=56). Clinics in Minnesota, USA Smokers uninterested in quitting smoking with a mean (SD) age of 44 (14) years and smoking 16 (7) cigarettes/day; 51% female, 72% White. During the experimental period the measures taken included: rate of alternative products used, amount of and abstinence from combusted tobacco used, and tobacco exposure biomarkers. There were higher rates of non-combustible alternative tobacco/nicotine product use in both VLNC conditions versus the NNC condition (rate ratio [RR]=2.18, 95% CI =1.94, 2.46 and RR=1.64, 95% CI=1.46, 1.85, respectively) and in VLNC1 versus VLNC2 condition (RR=1.33, 95% CI=1.23, 1.44), accompanied by reduced biomarkers of exposure primarily in VLNC2 condition (ps < 0.05). Fewer combusted products were smoked at almost all visits (ps ≤ 0.02) and there were higher rates of abstinence for both VLNC conditions compared with the NNC condition (VLNC1 versus NNC: RR = 9.96, 95% CI = 5.01, 19.81; VLNC2 versus NNC: RR = 11.23, 95% CI = 5.74, 21.97). The offer of, and instructions to use, reduced nicotine content cigarettes over an 8 week period led to greater use of alternative tobacco/nicotine products compared with continued use of normal nicotine cigarettes and also reductions in smoking rates.